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Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea

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Abstract

The aim of this paper was to observe the clinical effect of gentamycin combined with sodium bicarbonate for the prevention of irinotecan-induced diarrhea. A total of 98 patients with stage IV cancers were recruited and divided into a prevention group (52 patients) and a control group (46 patients). All patients received the chemotherapy including irinotecan. The prevention group received gentamycin and sodium bicarbonate before the use of irinotecan for 4 days; the control group did not receive any prevention. The use of gentamycin and sodium bicarbonate resulted in significantly higher stool pH (P<0.001), while the incidence of diarrhea by irinotecan was reduced (prevention group 13.70% versus control group 34.83%; P<0.001). Gentamycin combined with sodium bicarbonate appears to be useful in preventing the diarrhea induced by irinotecan and reducing the dosage of loperamide and fluid replacement.

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Authors and Affiliations

  1. The Cancer Center of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Qi Mei, Zhe Cao, Hua Xiong & Yuan Chen

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  1. Qi Mei
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  2. Zhe Cao
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  3. Hua Xiong
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  4. Yuan Chen
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Correspondence to Yuan Chen.

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Both authors contributed equally to this work

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Mei, Q., Cao, Z., Xiong, H. et al. Preliminary results of gentamycin combined with sodium bicarbonate for prevention of irinotecan-induced diarrhea. Front. Med. China 3, 470–474 (2009). https://doi.org/10.1007/s11684-009-0077-7

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  • DOI: https://doi.org/10.1007/s11684-009-0077-7

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