Loss of white matter connections after severe traumatic brain injury (TBI) and its relationship to social cognition

  • Skye McDonald
  • Katie I. Dalton
  • Jacqueline A. Rushby
  • Ramon Landin-Romero
Original Research

Abstract

Adults with severe traumatic brain injury (TBI) often suffer poor social cognition. Social cognition is complex, requiring verbal, non-verbal, auditory, visual and affective input and integration. While damage to focal temporal and frontal areas has been implicated in disorders of social cognition after TBI, the role of white matter pathology has not been examined. In this study 17 adults with chronic, severe TBI and 17 control participants underwent structural MRI scans and Diffusion Tensor Imaging. The Awareness of Social Inference Test (TASIT) was used to assess their ability to understand emotional states, thoughts, intentions and conversational meaning in everyday exchanges. Track-based spatial statistics were used to perform voxelwise analysis of Fractional Anisotropy (FA) and Mean Diffusivity (MD) of white matter tracts associated with poor social cognitive performance. FA suggested a wide range of tracts were implicated in poor TASIT performance including tracts known to mediate, auditory localisation (planum temporale) communication between nonverbal and verbal processes in general (corpus callosum) and in memory in particular (fornix) as well as tracts and structures associated with semantics and verbal recall (left temporal lobe and hippocampus), multimodal processing and integration (thalamus, external capsule, cerebellum) and with social cognition (orbitofrontal cortex, frontopolar cortex, right temporal lobe). Even when controlling for non-social cognition, the corpus callosum, fornix, bilateral thalamus, right external capsule and right temporal lobe remained significant contributors to social cognitive performance. This study highlights the importance of loss of white matter connectivity in producing complex social information processing deficits after TBI.

Keywords

Traumatic brain injury White matter Diffuse axonal injury Social cognition 

Notes

Funding

KD was supported by an ARC Discovery Project 15010026. JR was supported by NHMRC Project Grant 1081923. RLR is supported by the ARC Centre of Excellence in Cognition and its Disorders Memory Node (CE11000102) and by the Appenzeller Neuroscience Fellowship in Alzheimer’s Disease. Additional support was provided from the NHMRC Centre of Research Excellence in Brain Recovery and a former ARC DP 1094083.

Compliance with ethical standard

Conflict of interest

SM receives royalties for The Awareness of Social Inference Test. There are no other conflicts to declare.

Ethical approval

All procedures performed were in accordance with the ethical standards of the Human Research Ethics Advisory Panel (HREAP approval reference 103,049) at the University of New South Wales and complied with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11682_2018_9906_MOESM1_ESM.docx (16 kb)
ESM 1 (DOCX 16 kb)

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Authors and Affiliations

  1. 1.School of PsychologyUniversity of New South WalesSydneyAustralia
  2. 2.Brain and Mind CentreUniversity of SydneySydneyAustralia

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