Structural connectivity in spatial attention network: reconstruction from left hemispatial neglect
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Left hemispatial neglect (neglect) is an impaired state of spatial attention. We aimed to reconstruct structural connectivity in the spatial attention network and to identify disconnection patterns underlying neglect. We enrolled 59 right-handed patients who had their first-ever infarction in the right hemisphere and classified them into neglect group (34 patients with neglect) and control group (25 patients without neglect). The neglect group was further subcategorized into 6 subgroups based on infarcted vascular territories. Diffusion tensor imaging data were obtained from all patients. Fractional anisotropy maps were compared between neglect group/subgroups and the control group by using non-parametric voxel-based analysis, generating a lesion path mask. Probabilistic tractography analysis using the lesion path mask reconstructed the following structural connectivity in the spatial attention network, which is specifically damaged in neglect patients: (1) superior longitudinal fasciculus (SLF) I connecting the superior parietal lobule/intraparietal sulcus with the superior frontal gyrus/frontal eye field (SFG/FEF) (dorsal attention network); (2) SLF III/the arcuate fasciculus (AF) and the extreme capsule/inferior fronto-occipital fasciculus (IFOF) connecting the right inferior parietal lobule/temporoparietal junction/superior temporal gyrus (IPL/TPJ/STG) with the middle frontal gyrus/inferior frontal gyrus (ventral attention network); (3) the thalamic radiations to the spatial attention-related cortices; and (4) SLF II and IFOF interconnecting dorsal and ventral attention networks. Individual analysis indicated that isolated damage in SLF I, SLF II, SLF III/AF or the thalamic radiations to IPL/TPJ/STG due to posterior cerebral artery infarction, or simultaneous damage in four thalamic radiations due to anterior choroidal artery infarction, underlies different phenotypes of neglect.
KeywordsLeft hemispatial neglect Diffusion tensor imaging Structural connectivity
We would like to thank Devera G. Schoenberg, M.Sc. Editor and the NIH Fellows Editorial Board, for reviewing the manuscript.
Compliance with ethical standards
This study was supported by Comprehensive Brain Science Network, Japan.
Conflict of interest
All authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
- Asanuma, C., Andersen, R. A., & Cowan, W. M. (1985). The thalamic relations of the caudal inferior parietal lobule and the lateral prefrontal cortex in monkeys: Divergent cortical projections from cell clusters in the medial pulvinar nucleus. The Journal of Comparative Neurology, 241(3), 357–381.CrossRefPubMedGoogle Scholar
- Budisavljevic, S., Dell'Acqua, F., Zanatto, D., Begliomini, C., Miotto, D., Motta, R., et al. (2016). Asymmetry and structure of the fronto-parietal networks underlie Visuomotor processing in humans. Cereb Cortex. doi: 10.1093/cercor/bhv348.
- Chechlacz, M., Rotshtein, P., Bickerton, W. L., Hansen, P. C., Deb, S., & Humphreys, G. W. (2010). Separating neural correlates of allocentric and egocentric neglect: distinct cortical sites and common white matter disconnections. Cognitive Neuropsychology, 27(3), 277–303.CrossRefPubMedGoogle Scholar
- Fox, M. D., Corbetta, M., Snyder, A. Z., Vincent, J. L., & Raichle, M. E. (2006). Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems. Proceedings of the National Academy of Sciences of the United States of America, 103(26), 10046–10051.CrossRefPubMedPubMedCentralGoogle Scholar
- Ishiai, S. (1999). Behavioral inattention test (Japanese ed.). Tokyo: Shinkoh Igaku Shuppan.Google Scholar
- Mesulam, M. M. (1999). Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 354(1387), 1325–1346.CrossRefPubMedPubMedCentralGoogle Scholar
- Sarubbo, S., De Benedictis, A., Maldonado, I. L., Basso, G., & Duffau, H. (2013). Frontal terminations for the inferior fronto-occipital fascicle: anatomical dissection, DTI study and functional considerations on a multi-component bundle. Brain Structure & Function, 218(1), 21–37.CrossRefGoogle Scholar
- Thiebaut de Schotten, M., Tomaiuolo, F., Aiello, M., Merola, S., Silvetti, M., Lecce, F., et al. (2014). Damage to white matter pathways in subacute and chronic spatial neglect: a group study and 2 single-case studies with complete virtual "in vivo" tractography dissection. Cerebral Cortex, 24(3), 691–706.CrossRefPubMedGoogle Scholar
- Vernet, M., Quentin, R., Chanes, L., Mitsumasu, A., & Valero-Cabre, A. (2014). Frontal eye field, where art thou? Anatomy, function, and non-invasive manipulation of frontal regions involved in eye movements and associated cognitive operations. Frontiers in Integrative Neuroscience, 8, 66.PubMedPubMedCentralGoogle Scholar