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Brain Imaging and Behavior

, Volume 12, Issue 2, pp 309–323 | Cite as

Structural connectivity in spatial attention network: reconstruction from left hemispatial neglect

  • Takaaki Hattori
  • Kenji Ito
  • Chika Nakazawa
  • Yoshiyuki Numasawa
  • Mayumi Watanabe
  • Shigeki Aoki
  • Hidehiro Mizusawa
  • Sumio Ishiai
  • Takanori Yokota
Original Research

Abstract

Left hemispatial neglect (neglect) is an impaired state of spatial attention. We aimed to reconstruct structural connectivity in the spatial attention network and to identify disconnection patterns underlying neglect. We enrolled 59 right-handed patients who had their first-ever infarction in the right hemisphere and classified them into neglect group (34 patients with neglect) and control group (25 patients without neglect). The neglect group was further subcategorized into 6 subgroups based on infarcted vascular territories. Diffusion tensor imaging data were obtained from all patients. Fractional anisotropy maps were compared between neglect group/subgroups and the control group by using non-parametric voxel-based analysis, generating a lesion path mask. Probabilistic tractography analysis using the lesion path mask reconstructed the following structural connectivity in the spatial attention network, which is specifically damaged in neglect patients: (1) superior longitudinal fasciculus (SLF) I connecting the superior parietal lobule/intraparietal sulcus with the superior frontal gyrus/frontal eye field (SFG/FEF) (dorsal attention network); (2) SLF III/the arcuate fasciculus (AF) and the extreme capsule/inferior fronto-occipital fasciculus (IFOF) connecting the right inferior parietal lobule/temporoparietal junction/superior temporal gyrus (IPL/TPJ/STG) with the middle frontal gyrus/inferior frontal gyrus (ventral attention network); (3) the thalamic radiations to the spatial attention-related cortices; and (4) SLF II and IFOF interconnecting dorsal and ventral attention networks. Individual analysis indicated that isolated damage in SLF I, SLF II, SLF III/AF or the thalamic radiations to IPL/TPJ/STG due to posterior cerebral artery infarction, or simultaneous damage in four thalamic radiations due to anterior choroidal artery infarction, underlies different phenotypes of neglect.

Keywords

Left hemispatial neglect Diffusion tensor imaging Structural connectivity 

Notes

Acknowledgements

We would like to thank Devera G. Schoenberg, M.Sc. Editor and the NIH Fellows Editorial Board, for reviewing the manuscript.

Compliance with ethical standards

Funding

This study was supported by Comprehensive Brain Science Network, Japan.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

11682_2017_9698_MOESM1_ESM.docx (20 kb)
Supplementary Table 1 (DOCX 19 kb)
11682_2017_9698_MOESM2_ESM.docx (24 kb)
Supplementary Table 2 (DOCX 24 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Takaaki Hattori
    • 1
  • Kenji Ito
    • 2
  • Chika Nakazawa
    • 3
  • Yoshiyuki Numasawa
    • 1
  • Mayumi Watanabe
    • 3
  • Shigeki Aoki
    • 4
  • Hidehiro Mizusawa
    • 5
  • Sumio Ishiai
    • 6
  • Takanori Yokota
    • 1
  1. 1.Department of Neurology and Neurological ScienceTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Division of Ultra-High Field MRI, Institute for Biomedical SciencesIwate Medical UniversityIwateJapan
  3. 3.Department of RehabilitationJA Toride Medical CenterIbarakiJapan
  4. 4.Department of RadiologyJuntendo UniversityTokyoJapan
  5. 5.National Center of Neurology and PsychiatryTokyoJapan
  6. 6.Department for RehabilitationSapporo Medical UniversitySapporoJapan

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