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Reduced volume of gray matter in patients with trigeminal neuralgia

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Abstract

Accumulating evidence from brain structural imaging studies has supported that chronic pain could induce changes in brain gray matter volume. However, few studies have focused on the gray matter alterations of Trigeminal neuralgia (TN). In this study, twenty-eight TN patients (thirteen females; mean age, 45.86 years ±11.17) and 28 healthy controls (HC; thirteen females; mean age, 44.89 years ±7.67) were included. Using voxel-based morphometry (VBM), we detected abnormalities in gray matter volume in the TN patients. Based on a voxel-wise analysis, the TN group showed significantly decreased gray matter volume in the bilateral superior/middle temporal gyrus (STG/MTG), bilateral parahippocampus, left anterior cingulate cortex (ACC), caudate nucleus, right fusiform gyrus, and right cerebellum compared with the HC. In addition, we found that the gray matter volume in the bilateral STG/MTG was negatively correlated with the duration of TN. These results provide compelling evidence for gray matter abnormalities in TN and suggest that the duration of TN may be a critical factor associated with brain alterations.

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References

  • Apkarian, A. V., Bushnell, M. C., Treede, R. D., & Zubieta, J. K. (2005). Human brain mechanisms of pain perception and regulation in health and disease. European Journal of Pain, 9(4), 463–484. doi:10.1016/j.ejpain.2004.11.001.

    Article  PubMed  Google Scholar 

  • Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., et al. (2004). Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. The Journal of Neuroscience, 24(46), 10410–10415. doi:10.1523/JNEUROSCI.2541-04.2004.

    Article  CAS  PubMed  Google Scholar 

  • Ashburner, J. (2007). A fast diffeomorphic image registration algorithm. NeuroImage, 38(1), 95–113. doi:10.1016/j.neuroimage.2007.07.007.

    Article  PubMed  Google Scholar 

  • Baliki, M. N., Schnitzer, T. J., Bauer, W. R., & Apkarian, A. V. (2011). Brain morphological signatures for chronic pain. PloS One, 6(10), e26010. doi:10.1371/journal.pone.0026010.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blankstein, U., Chen, J., Diamant, N. E., & Davis, K. D. (2010). Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors. Gastroenterology, 138(5), 1783–1789. doi:10.1053/j.gastro.2009.12.043.

    Article  PubMed  Google Scholar 

  • Brett, M., Anton, J.-L., Valabregue, R., & Poline, J.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. NeuroImage, 16(2), S497.

    Google Scholar 

  • Buchsbaum, B. R., Hickok, G., & Humphries, C. (2001). Role of left posterior Superior temporal gyrus in phonological processing for speech perception and production. Cognitive Science, 25, 663–678.

    Article  Google Scholar 

  • Buvanendran, A., Ali, A., Stoub, T. R., Berger, R. A., & Kroin, J. S. (2007). The use of brain positron emission tomography to identify sites of postoperative pain processing with and without epidural analgesia. Anesthesia and Analgesia, 105, 1784–1786.

    Article  PubMed  Google Scholar 

  • Chen, F. Y., Tao, W., & Li, Y. J. (2008). Advances in brain imaging of neuropathic pain. Chinese Medical Journal, 121(7), 653–657.

    PubMed  Google Scholar 

  • D’Amour, D., Dubois, C. A., Tchouaket, E., Clarke, S., & Blais, R. (2014). The occurrence of adverse events potentially attributable to nursing care in medical units: cross sectional record review. International Journal of Nursing Studies, 51(6), 882–891. doi:10.1016/j.ijnurstu.2013.10.017.

    Article  PubMed  Google Scholar 

  • Desouza, D. D., Moayedi, M., Chen, D. Q., Davis, K. D., & Hodaie, M. (2013). Sensorimotor and pain modulation brain abnormalities in trigeminal neuralgia: A paroxysmal, sensory-triggered neuropathic pain. PloS One, 8(6), e66340. doi:10.1371/journal.pone.0066340.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Freund, W., Klug, R., Weber, F., Stuber, G., Schmitz, B., & Wunderlich, A. P. (2009). Perception and suppression of thermally induced pain: a fMRI study. Somatosensory & Motor Research, 26(1), 1–10. doi:10.1080/08990220902738243.

    Article  CAS  Google Scholar 

  • Geha, P. Y., Baliki, M. N., Harden, R. N., Bauer, W. R., Parrish, T. B., & Apkarian, A. V. (2008). The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions. Neuron, 60(4), 570–581. doi:10.1016/j.neuron.2008.08.022.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gustin, S. M., Peck, C. C., Wilcox, S. L., Nash, P. G., Murray, G. M., & Henderson, L. A. (2011). Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. The Journal of Neuroscience, 31(16), 5956–5964. doi:10.1523/JNEUROSCI.5980-10.2011.

    Article  CAS  PubMed  Google Scholar 

  • Headache Classification Committee of the International Headache S (2013). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia, 33(9), 629–808. doi:10.1177/0333102413485658.

    Article  Google Scholar 

  • Hsu, M. C., Harris, R. E., Sundgren, P. C., Welsh, R. C., Fernandes, C. R., Clauw, D. J., et al. (2009). No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder. Pain, 143(3), 262–267. doi:10.1016/j.pain.2009.03.017.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim, J. H., Suh, S. I., Seol, H. Y., Oh, K., Seo, W. K., Yu, S. W., et al. (2008). Regional grey matter changes in patients with migraine: a voxel-based morphometry study. Cephalalgia, 28(6), 598–604. doi:10.1111/j.1468-2982.2008.01550.x.

    Article  CAS  PubMed  Google Scholar 

  • Kuchinad, A., Schweinhardt, P., Seminowicz, D. A., Wood, P. B., Chizh, B. A., & Bushnell, M. C. (2007). Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? The Journal of Neuroscience, 27(15), 4004–4007. doi:10.1523/JNEUROSCI.0098-07.2007.

    Article  CAS  PubMed  Google Scholar 

  • Liotti, M., Mayberg, H. S., Brannan, S. K., McGinnis, S., Jerabek, P., & Fox, P. T. (2000). Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders. Biological Psychiatry, 48, 30–42.

    Article  CAS  PubMed  Google Scholar 

  • May, A. (2011). Structural brain imaging: a window into chronic pain. The Neuroscientist, 17(2), 209–220. doi:10.1177/1073858410396220.

    Article  PubMed  Google Scholar 

  • Obermann, M., Rodriguez-Raecke, R., Naegel, S., Holle, D., Mueller, D., Yoon, M. S., et al. (2013). Gray matter volume reduction reflects chronic pain in trigeminal neuralgia. NeuroImage, 74, 352–358. doi:10.1016/j.neuroimage.2013.02.029.

    Article  PubMed  Google Scholar 

  • Parise, M., Kubo, T. T., Doring, T. M., Tukamoto, G., Vincent, M., & Gasparetto, E. L. (2014). Cuneus and fusiform cortices thickness is reduced in trigeminal neuralgia. The Journal of Headache and Pain, 15, 17. doi:10.1186/1129-2377-15-17.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997). Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science, 277(5328), 968–971.

    Article  CAS  PubMed  Google Scholar 

  • Richardson, M. P., Strange, B. A., & Dolan, R. J. (2004). Encoding of emotional memories depends on amygdala and hippocampus and their interactions. Nature Neuroscience, 7(3), 278–285. doi:10.1038/nn1190.

    Article  CAS  PubMed  Google Scholar 

  • Rocca, M. A., Ceccarelli, A., Falini, A., Colombo, B., Tortorella, P., Bernasconi, L., et al. (2006). Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke, 37(7), 1765–1770. doi:10.1161/01.STR.0000226589.00599.4d.

    Article  PubMed  Google Scholar 

  • Rocca, M. A., Messina, R., Colombo, B., Falini, A., Comi, G., & Filippi, M. (2014). Structural brain MRI abnormalities in pediatric patients with migraine. Journal of Neurology, 261(2), 350–357. doi:10.1007/s00415-013-7201-y.

    Article  PubMed  Google Scholar 

  • Rottmann, S., Jung, K., Vohn, R., & Ellrich, J. (2010). Long-term depression of pain-related cerebral activation in healthy man: an fMRI study. European Journal of Pain, 14(6), 615–624. doi:10.1016/j.ejpain.2009.10.006.

    Article  PubMed  Google Scholar 

  • Schmidt-Wilcke, T. (2008). Variations in brain volume and regional morphology associated with chronic pain. Current Rheumatology Reports, 10(6), 467–474.

    Article  PubMed  Google Scholar 

  • Schmidt-Wilcke, T., Hierlmeier, S., & Leinisch, E. (2010). Altered regional brain morphology in patients with chronic facial pain. Headache, 50(8), 1278–1285. doi:10.1111/j.1526-4610.2010.01637.x.

    Article  PubMed  Google Scholar 

  • Schmidt-Wilcke, T., Leinisch, E., Straube, A., Kampfe, N., Draganski, B., Diener, H. C., et al. (2005). Gray matter decrease in patients with chronic tension type headache. Neurology, 65(9), 1483–1486. doi:10.1212/01.wnl.0000183067.94400.80.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt-Wilcke, T., Luerding, R., Weigand, T., Jurgens, T., Schuierer, G., Leinisch, E., et al. (2007). Striatal grey matter increase in patients suffering from fibromyalgia–a voxel-based morphometry study. Pain, 132 Suppl 1, S109-116. doi:10.1016/j.pain.2007.05.010.

  • Schweinhardt, P. & Bushnell, M. C. (2010). Pain imaging in health and disease–how far have we come? The Journal of Clinical Investigation, 120(11), 3788–3797. doi:10.1172/JCI43498.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J., Clauw, D. J., et al. (2013). Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume. The Journal of Pain, 14(7), 663–675. doi:10.1016/j.jpain.2013.03.001.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ter Minassian, A., Ricalens, E., Humbert, S., Duc, F., Aube, C., & Beydon, L. (2013). Dissociating anticipation from perception: acute pain activates default mode network. Human Brain Mapping, 34(9), 2228–2243. doi:10.1002/hbm.22062.

    Article  PubMed  Google Scholar 

  • Valet, M., Gundel, H., Sprenger, T., Sorg, C., Muhlau, M., Zimmer, C., et al. (2009). Patients with pain disorder show gray-matter loss in pain-processing structures: a voxel-based morphometric study. Psychosomatic Medicine, 71(1), 49–56. doi:10.1097/PSY.0b013e31818d1e02.

    Article  PubMed  Google Scholar 

  • Valfre, W., Rainero, I., Bergui, M., & Pinessi, L. (2008). Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache, 48(1), 109–117. doi:10.1111/j.1526-4610.2007.00723.x.

    Article  PubMed  Google Scholar 

  • Villarreal, G., Hamilton, D. A., Petropoulos, H., Driscoll, I., Rowland, L. M., Griego, J. A., et al. (2002). Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder. Biological Psychiatry, 52(2), 119–125.

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was funded by the National Natural Science Foundation of China (Grant numbers: 81471639), the Science and Technology Planning Project of Guangdong Province, China (Grant numbers: 2012A030400019 and 2013B021800172).

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Authors and Affiliations

  1. Department of Medical Imaging, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, 510317, People’s Republic of China

    Meng Li, Jianhao Yan, Shumei Li, Tianyue Wang, Wenfeng Zhan, Hua Wen, Xiaofen Ma, Junzhang Tian & Guihua Jiang

  2. Department of Neurosurgery, Guangdong No. 2 Provincial People’s Hospital, Guangzhou, 510317, People’s Republic of China

    Yong Zhang

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  1. Meng Li
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  2. Jianhao Yan
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  9. Junzhang Tian
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  10. Guihua Jiang
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Correspondence to Guihua Jiang.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Conflict of interest

Author Meng Li, Jianhao Yan, Shumei Li, Tianyue Wang, Wenfeng Zhan, Hua Wen, Xiaofen Ma, Yong Zhang, Junzhang Tian, Guihua Jiang declare that they have no conflict of interest.

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Li, M., Yan, J., Li, S. et al. Reduced volume of gray matter in patients with trigeminal neuralgia. Brain Imaging and Behavior 11, 486–492 (2017). https://doi.org/10.1007/s11682-016-9529-2

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