Reduced volume of gray matter in patients with trigeminal neuralgia
- 333 Downloads
Accumulating evidence from brain structural imaging studies has supported that chronic pain could induce changes in brain gray matter volume. However, few studies have focused on the gray matter alterations of Trigeminal neuralgia (TN). In this study, twenty-eight TN patients (thirteen females; mean age, 45.86 years ±11.17) and 28 healthy controls (HC; thirteen females; mean age, 44.89 years ±7.67) were included. Using voxel-based morphometry (VBM), we detected abnormalities in gray matter volume in the TN patients. Based on a voxel-wise analysis, the TN group showed significantly decreased gray matter volume in the bilateral superior/middle temporal gyrus (STG/MTG), bilateral parahippocampus, left anterior cingulate cortex (ACC), caudate nucleus, right fusiform gyrus, and right cerebellum compared with the HC. In addition, we found that the gray matter volume in the bilateral STG/MTG was negatively correlated with the duration of TN. These results provide compelling evidence for gray matter abnormalities in TN and suggest that the duration of TN may be a critical factor associated with brain alterations.
KeywordsTrigeminal neuralgia Gray matter volume Disease duration VBM
This work was funded by the National Natural Science Foundation of China (Grant numbers: 81471639), the Science and Technology Planning Project of Guangdong Province, China (Grant numbers: 2012A030400019 and 2013B021800172).
Compliance with ethical standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Conflict of interest
Author Meng Li, Jianhao Yan, Shumei Li, Tianyue Wang, Wenfeng Zhan, Hua Wen, Xiaofen Ma, Yong Zhang, Junzhang Tian, Guihua Jiang declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
- Apkarian, A. V., Sosa, Y., Sonty, S., Levy, R. M., Harden, R. N., Parrish, T. B., et al. (2004). Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. The Journal of Neuroscience, 24(46), 10410–10415. doi: 10.1523/JNEUROSCI.2541-04.2004.CrossRefPubMedGoogle Scholar
- Brett, M., Anton, J.-L., Valabregue, R., & Poline, J.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. NeuroImage, 16(2), S497.Google Scholar
- D’Amour, D., Dubois, C. A., Tchouaket, E., Clarke, S., & Blais, R. (2014). The occurrence of adverse events potentially attributable to nursing care in medical units: cross sectional record review. International Journal of Nursing Studies, 51(6), 882–891. doi: 10.1016/j.ijnurstu.2013.10.017.CrossRefPubMedGoogle Scholar
- Desouza, D. D., Moayedi, M., Chen, D. Q., Davis, K. D., & Hodaie, M. (2013). Sensorimotor and pain modulation brain abnormalities in trigeminal neuralgia: A paroxysmal, sensory-triggered neuropathic pain. PloS One, 8(6), e66340. doi: 10.1371/journal.pone.0066340.CrossRefPubMedPubMedCentralGoogle Scholar
- Geha, P. Y., Baliki, M. N., Harden, R. N., Bauer, W. R., Parrish, T. B., & Apkarian, A. V. (2008). The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions. Neuron, 60(4), 570–581. doi: 10.1016/j.neuron.2008.08.022.CrossRefPubMedPubMedCentralGoogle Scholar
- Gustin, S. M., Peck, C. C., Wilcox, S. L., Nash, P. G., Murray, G. M., & Henderson, L. A. (2011). Different pain, different brain: thalamic anatomy in neuropathic and non-neuropathic chronic pain syndromes. The Journal of Neuroscience, 31(16), 5956–5964. doi: 10.1523/JNEUROSCI.5980-10.2011.CrossRefPubMedGoogle Scholar
- Hsu, M. C., Harris, R. E., Sundgren, P. C., Welsh, R. C., Fernandes, C. R., Clauw, D. J., et al. (2009). No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder. Pain, 143(3), 262–267. doi: 10.1016/j.pain.2009.03.017.CrossRefPubMedPubMedCentralGoogle Scholar
- Kuchinad, A., Schweinhardt, P., Seminowicz, D. A., Wood, P. B., Chizh, B. A., & Bushnell, M. C. (2007). Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? The Journal of Neuroscience, 27(15), 4004–4007. doi: 10.1523/JNEUROSCI.0098-07.2007.CrossRefPubMedGoogle Scholar
- Schmidt-Wilcke, T., Luerding, R., Weigand, T., Jurgens, T., Schuierer, G., Leinisch, E., et al. (2007). Striatal grey matter increase in patients suffering from fibromyalgia–a voxel-based morphometry study. Pain, 132 Suppl 1, S109-116. doi: 10.1016/j.pain.2007.05.010.
- Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J., Clauw, D. J., et al. (2013). Structural brain anomalies and chronic pain: a quantitative meta-analysis of gray matter volume. The Journal of Pain, 14(7), 663–675. doi: 10.1016/j.jpain.2013.03.001.CrossRefPubMedPubMedCentralGoogle Scholar
- Valet, M., Gundel, H., Sprenger, T., Sorg, C., Muhlau, M., Zimmer, C., et al. (2009). Patients with pain disorder show gray-matter loss in pain-processing structures: a voxel-based morphometric study. Psychosomatic Medicine, 71(1), 49–56. doi: 10.1097/PSY.0b013e31818d1e02.CrossRefPubMedGoogle Scholar