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Brain Imaging and Behavior

, Volume 11, Issue 2, pp 444–453 | Cite as

Disrupted brain connectivity networks in acute ischemic stroke patients

  • Yifei Zhu
  • Lin Bai
  • Panpan Liang
  • Shan Kang
  • Hengbo Gao
  • Haiqing Yang
Original Research

Abstract

Neuroimaging studies have shown that local brain lesions could result in abnormal information transfer far from the lesion site in acute ischemic stroke (AIS) patients; yet, little is known about alternations of the topological organization of whole-brain networks in AIS. By using resting state functional magnetic resonance imaging (MRI) and graph theory analysis, we systematically investigated the topological properties of the functional brain networks of 28 healthy controls (HC, age: 56.9 ± 0.45 years) and 29 AIS (age: 57.6 ± 0.21 years) with proximal anterior circulation occlusion within 12 h of symptom onset. In our results, both the AIS and HC groups exhibited small-world network organization, suggesting a functional balance between local specialization and global integration. However, compared with the HC, the AIS patients had a lower shortest path length and higher global efficiency, indicating a tendency of randomization in patients’ functional brain networks. The AIS patients had an increased nodal degree in the precuneus (PCUN), middle frontal gyrus (MFG), medial part of the superior frontal gyrus (SFGmed), orbital part of the middle frontal gyrus, and the opercular part of the inferior frontal gyrus, and increased nodal efficiency in the PUCN, MFG, SFGmed, and the angular gyrus. The decreased nodal degree in AIS was found in the heschl gyrus (HES), and no significant decreased nodal efficiency was observed. The dysfunctional connections were mainly concentrated in the HES and prefrontal cortex. Furthermore, the altered nodal centrality of the MFG and abnormal functional connectivity in AIS were associated with patients’ Mini-Mental State Examination scores. These results suggested that interrupted functional connectivity in language system organization after focal brain lesions could also result in disruptions in the topological organization of other brain circuits, and this may contribute to disturbances in cognition in AIS patients.

Keywords

Acute ischemic stroke Brain connectome Cognitive performance 

Notes

Acknowledgments

This work was supported by the Food and Drug Safety Science and Technology Project of Hebei provincial Food and Drug Administration under project No. ZD2015031.

Compliance with ethical standards

Conflict of interest

Yifei Zhu, Lin Bai, Panpan Liang, Shan Kang, Hengbo Gao, Haiqing Yang declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Ethical statements

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yifei Zhu
    • 1
  • Lin Bai
    • 1
  • Panpan Liang
    • 1
  • Shan Kang
    • 1
  • Hengbo Gao
    • 1
  • Haiqing Yang
    • 1
  1. 1.Department of NeurologyThe Second Hospital of Hebei Medical UniversityShijiazhuangPeople’s Republic of China

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