Brain Imaging and Behavior

, Volume 11, Issue 2, pp 417–429 | Cite as

The functional connectivity in the motor loop of human basal ganglia

  • Clara Rodriguez-Sabate
  • Magdalena Sabate
  • Catalina Llanos
  • Ingrid Morales
  • Alberto Sanchez
  • Manuel Rodriguez
Original Research

Abstract

Basal ganglia interact in a complex way which is still not completely understood. The model generally used to explain basal ganglia interactions is based on experimental data in animals, but its validation in humans has been hampered by methodological restrictions. The time-relationship (partial correlation) of the fluctuations of the blood-oxygen-level-dependent signals recorded in the main basal ganglia was used here (32 healthy volunteers; 18–72 years of age; 16 males and 16 females) to test whether the interaction of the main basal ganglia in humans follows the pattern of functional connectivity in animals. Data showed that most basal ganglia have a functional connectivity which is compatible with that of the established closed-loop model. The strength of the connectivity of some basal ganglia changed with finger motion, suggesting that the functional interactions between basal ganglia are quickly restructured by the motor tasks. The present study with the motor cortico-BG loop centers supports the circling dynamic of the basal ganglia model in humans, showing that motor tasks may change the functional connectivity of these centers.

Keywords

Cerebral cortex Basal ganglia Functional connectivity Resting state Hand motion 

Notes

Compliance with ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was performed with the approval of the local Institutional Human Studies Committee. This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Funding

This study was funded by the Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain. (grant number PI2011/02–2).

Conflict of Interest

Authors declare no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Clara Rodriguez-Sabate
    • 1
    • 3
  • Magdalena Sabate
    • 2
    • 3
  • Catalina Llanos
    • 2
  • Ingrid Morales
    • 1
    • 3
  • Alberto Sanchez
    • 1
    • 3
  • Manuel Rodriguez
    • 1
    • 3
  1. 1.Laboratory of Neurobiology and Experimental Neurology, Department of Physiology; Faculty of MedicineUniversity of La LagunaTenerifeSpain
  2. 2.Department of Pharmacology and Physical Medicine, Faculty of MedicineUniversity of La LagunaTenerifeSpain
  3. 3.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)MadridSpain

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