A case of pregnancy and lactation-associated osteoporosis and a review of the literature



The pregnancy and lactation-associated osteoporosis (PLO) is a rare disease whose precise pathophysiological mechanisms remain mostly unknown.

Case report

We reported here a case of PLO that occurred in the early postpartum period and led to multiple compression fractures. Combination therapy with alendronate, calcium carbonate, and vitamin D was used to treat the patient and a marked but gradual increase in the density of bone mineral was observed. Moreover, no further fractures have occurred.


PLO is a very rare type of osteoporosis associated with severe chronic back pain. Increased bone resorption significantly increases the risk of bone fractures in women with PLO. Early diagnosis, stopping breastfeeding, treatment of calcium and vitamin D, bisphosphonates, or other antiosteoporosis medicine and regular follow-ups of these cases are particularly important in the prevention of fractures and to increase the quality of life of patients.

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Correspondence to Pu Jia.

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Jia, P., Wang, R., Yuan, J. et al. A case of pregnancy and lactation-associated osteoporosis and a review of the literature. Arch Osteoporos 15, 94 (2020). https://doi.org/10.1007/s11657-020-00768-7

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  • Pregnancy and lactation-associated osteoporosis (PLO)
  • Alendronate
  • Pathogenesis
  • Treatment