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A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females

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Abstract

Summary

This study examined the effects of weekly 35,000 IU vitamin D supplementation for 4 weeks on bone turnover markers (BTMs). There was improvement in the levels of parathyroid hormone (PTH), osteocalcin, and carboxy-terminal telopeptides of crosslinks of type 1 collagen (βCTX) which paralleled the increase in vitamin D levels.

Purpose

The effects of vitamin D supplementation on bone turnover markers (BTMs) have been inconsistent. This study examined the effects of weekly 35,000 IU vitamin D supplementation for 1 month on BTMs.

Methods

Sixty-eight vitamin D deficient adolescent females were given 35,000 IU of vitamin D3 for 4 weeks. Pre and post intervention blood samples were taken for 25(OH) D, PTH, osteocalcin and βCTX.

Results

There was a significant increase in serum 25 (OH) D in the post intervention period which was accompanied by a significant decrease in PTH, osteocalcin and βCTX (P < 0.001).

Conclusions

We concluded that weekly 35,000 IU vitamin D supplementation for 4 weeks results in significant improvement of BTMs.

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Authors and Affiliations

  1. Department of Medicine, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia

    Riad A. Sulimani

  2. Department of Community and Family Medicine, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia

    Ashry G. Mohammed

  3. Department of School Health, Ministry of Health, Riyadh, Saudi Arabia

    Suliman N. Alshehri

  4. Obesity Research Center, College of Medicine, King Saud University, Riyadh, 7805, Saudi Arabia

    Assim A. Alfadda

  5. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia

    Abdulaziz Al-Othman

  6. Divisions Endocrinology and Geriatrics, McMaster University, 331-209 Sheddon Drive, Oakville, ON, L6J 1X8, Canada

    Aliya A. Khan

Authors
  1. Riad A. Sulimani
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  2. Ashry G. Mohammed
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  3. Suliman N. Alshehri
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  4. Assim A. Alfadda
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  5. Abdulaziz Al-Othman
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  6. Aliya A. Khan
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Correspondence to Riad A. Sulimani.

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Sulimani, R.A., Mohammed, A.G., Alshehri, S.N. et al. A weekly 35,000 IU vitamin D supplementation improves bone turnover markers in vitamin D deficient Saudi adolescent females. Arch Osteoporos 12, 85 (2017). https://doi.org/10.1007/s11657-017-0379-3

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  • DOI: https://doi.org/10.1007/s11657-017-0379-3

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