Chinese Journal of Integrative Medicine

, Volume 24, Issue 3, pp 232–236 | Cite as

Chinese Experts Consensus on Clinical Application of Naoxintong Capsule (脑心通胶囊)

  • Liu Long-tao
Regulation and Guideline
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References

  1. 1.
    Wei PF, Zhang SY, Jiao CL. Effect of Naoxintong Capsule on hemorheology of acute blood stasis syndrome in rats. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2003;1:463–465.Google Scholar
  2. 2.
    Wang H, Zhong WJ, Huang MW, Wu XY, Chen H. Efficacy of dual antiplatelet therapy combined with Naoxintong Capsules following coronary microembolization induced by homologous microthrombi in rats. Chin J Integr Med 2011;17:917–924.CrossRefPubMedGoogle Scholar
  3. 3.
    Chen H, Zhang Y, Wu X, Li C, Wang H. In vitro assessment of cytochrome P450 2C19 potential of Naoxintong. Evid Based Complement Alternat Med 2012;2012:430262.PubMedPubMedCentralGoogle Scholar
  4. 4.
    Sun H, Lou XY, Wu XY, Wang H, Qu Q, Tan SL, et al. Up-regulation of CYP2C19 expression by Buchang Naoxintong via PXR activation in HepG2 cells. PLoS One 2016;11:e0160285.Google Scholar
  5. 5.
    Chen H, Yu GW, Sun H, Wu XY, Wang H. Comparison of adjunctive Naoxintong versus clopidogrel in volunteers with the CYP2 C19 2 gene mutation accompanied with qi deficiency and blood stasis constitution. Evid Based Complement Alternat Med 2011;2011:207034.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Chen H, Wu XY, Wu HX, Wang H. A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism. Chin J Integr Med 2014;20:894–902.CrossRefPubMedGoogle Scholar
  7. 7.
    Zheng YB, Zhang Y, Li CD, Chen H. Effect of Naoxintong Capsule on antithrombotic therapy after percutaneous coronary intervention in 27 cases. J Tradit Chin Med (Chin) 2015;52:299–303.Google Scholar
  8. 8.
    Yun L, Liu JT, Li XK, Gou Wei, Li JL. Effect of Naoxintong Capsule on acute myocardial ischemia in dogs. Northwest Pharm J (Chin) 2004;19:258–260.Google Scholar
  9. 9.
    Wang Y, Yan X, Mi S, Li Z, Wang Y, Zhu H, et al. Naoxintong attenuates ischaemia/reperfusion injury through inhibiting NLRP3 inflammasome activation. J Cell Mol Med 2017;21:4–12.CrossRefPubMedGoogle Scholar
  10. 10.
    Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, et al. Naoxintong inhibits the advanced atherosclerosis and enhances the plaque stability in apolipoprotein E deficient mice J. Cardiovasc Pharmacol 2016;67:203–211.CrossRefGoogle Scholar
  11. 11.
    Dong B, Yu YH, Liu ZZ, Liu Y, Luo M, Zhang J, et al. Exploration on protective effect of Naoxintong on arteriosclerosis in endothelial function of rabbits. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2005;3:328–329.Google Scholar
  12. 12.
    Dong B, Yu YH, Liu ZZ, Liu Y, Zhang J, Xu XQ, et al. Effect of Naoxintong on MCP-1 gene in experimental arteriosclerosis rabbits. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2005;3:411–412.CrossRefGoogle Scholar
  13. 13.
    Yao J, Xie XL, Xie LD, Wang HJ, Xu CS. Effect of Naoxintong on myocardial fibrosis in spontaneously hypertensive rats. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2008;6:188–190.Google Scholar
  14. 14.
    Xu H, Jin J, Chen L, Li CX, Xu QG, Shi JJ, et al. Naoxintong/PPAR signaling inhibits H9c2 cell apoptosis and autophagy in response to oxidative stress. Evid Based Complement Alternat Med 2016;2016:4370381.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Liu MT, Liu X, Wang HP, Xiao HB, Jing F, Tang LY, et al. Metabolomics study on the effects of Buchang Naoxintong capsules for treating cerebral ischemia in rats using UPLC-Q/TOF-MS. J Ethnopharmacol 2016;2016:1–11.CrossRefGoogle Scholar
  16. 16.
    Zhang WW, Li YZ, Qiu LQ, Huang YH. Neuroprotective effect of Buchang Naoxintong Capsule on cerebral ischemia reperfusion injury in rats. J Clin Neurol (Chin) 2006;19:118–120.Google Scholar
  17. 17.
    Xue J, Zhang XJ, Zhang C, Kang N, Liu XX, Yu JY, et al. Protective effect of Naoxintong against cerebral ischemia reperfusion injury in mice. J Ethnopharmacol 2016;182:181–189.CrossRefPubMedGoogle Scholar
  18. 18.
    Chen J, Lu YQ, Lyu HH. Protective effect of Buchang Naoxintong Capsule on cerebral ischemia reperfusion injury in rats. Chin J Rehabi Theory Pract (Chin) 2009;15:138–140.Google Scholar
  19. 19.
    Liu SM, He MD, Su NX. Effects of Naoxintong Capsules on behavior and hippocampal morphology in vascular dementia rats. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2006;4:35–36.CrossRefGoogle Scholar
  20. 20.
    Wei R, He MD, Liu SM, Li H, Wang Z. Effect of Buchang Naoxintong on learning and memory and vascular endothelial growth factor in vascular dementia rats. J Apopl Nerv Dis 2006;23:306–309.Google Scholar
  21. 21.
    Yang Y, Zeng LX. A meta-analysis of the clinical efficacy and safety of Naoxintong Capsule in the treatment of angina pectoris of coronary heart disease. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2012:4:97–100.Google Scholar
  22. 22.
    Hou JH, Zhang LL, Li JM, Wang YH, Zheng Y. Meta analysis of the clinical efficacy and safety of Naoxintong Capsule in treatment of unstable angina pectoris. Modern Biomed Progr (Chin) 2014;14:1545–1549.Google Scholar
  23. 23.
    Na JT, Tang BZ, Yu XY. Effect of Buchang Naoxintong on secondary preventing of 248 cases of myocardial infarction. Harbin Med J (Chin) 2011;31:162–163.Google Scholar
  24. 24.
    Zhong F, Li W, Li YH. Effect of Naoxintong Capsule on secondary prevention of myocardial infarction. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2014;12:416–418.Google Scholar
  25. 25.
    Sun YN. Clinical analysis of Naoxintong Capsule in treating 310 cases of cerebral infarction. Chin Pract Med (Chin) 2010;5:164–165.Google Scholar
  26. 26.
    Sun LH, Zhang C, Yan H, Zeng LX. Meta analysis of efficacy and safety of Naoxintong in treating cerebral infarction. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2012;10:1182–1186.Google Scholar
  27. 27.
    Li JK. A randomized controlled study of Naoxintong Capsule in treatment of ischemic stroke in acute phase. Shandong Med J (Chin) 2006;46:35–37.Google Scholar
  28. 28.
    Ying ZH, Ma LH, Li KJ. Systematic evaluation of Naoxintong Capsule in treating acute ischemic stroke. Shandong Med J (Chin) 2010;29:665–666.Google Scholar
  29. 29.
    Yang L, Guo Y. Meta analysis of Naoxintong Capsule in treating transient ischemic brain attack. Pharmocol Clin Chin Mater Med (Chin) 2015;31:202–206.Google Scholar
  30. 30.
    Liu Y, Yao H. Clinical observation on Naoxintong Capsule in treating vertebra-basilar artery transient ischemic attack. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2009;7:1170–1171.Google Scholar
  31. 31.
    Shen XZ. Clinical observation on effect of Naoxintong in combination with Western medicine on prevention and treatment of 60 cases of transient ischemic attacks. Chin Pract Med (Chin) 2009;4:147–148.Google Scholar
  32. 32.
    Deng SL, Zou ZY, Li J. Clinical observation on Naoxintong Capsule in treating senile transient ischemic attack. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2007;5:179–180.Google Scholar
  33. 33.
    Liu B, Zhang YP. Clinical observation of Buchang Naoxintong on insufficient blood supply of vertebrobasilar artery in senile patients. Chin Pract Med (Chin) 2010;5:137–138.Google Scholar
  34. 34.
    Wang LQ. Naoxintong Capsule treatment of vertebrobasilar insufficiency in 100 cases. Guangming Tradit Chin Med (Chin) 2011;26:87–88.Google Scholar
  35. 35.
    Cheng L. Naoxintong in the treatment of vertebra-basilar insufficiency in 80 cases. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2005;3:1123–1124.Google Scholar
  36. 36.
    Zhang JL, Jin XQ, Liu Y. Effect of Naoxintong Capsule on clinical symptoms and intima-media thickness in patients with carotid atherosclerosis. Chin J Integr Med Cardio-/Cerebrovasc Dis (Chin) 2006;4:401–402.Google Scholar
  37. 37.
    Wen ZY. Effect of Naoxintong Capsules on carotid atherosclerotic plaques. Pract Cardiac Cerebr Pneum Vasc Dis (Chin) 2011;19:41–42.Google Scholar

Copyright information

© Chinese Association of the Integration of Traditional and Western Medicine 2018

Authors and Affiliations

  • Liu Long-tao
    • 1
  1. 1.Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijingChina

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