Essence of “Shen (Kidney) Controlling Bones”: Conceptual Analysis Based on Hypothalamic-Pituitary-Adrenal-Osteo-Related Cells Axis
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As a traditional concept of Chinese medicine (CM), the theory of “Shen (Kidney) controlling bones” has been gradually proven. And in modern allopathic medicine, the multiple mechanisms of bone growth, development and regeneration align with the theory. Shen deficiency as a pathological condition has a negative effect on the skeleton of body, specifically the disorder of bone homeostasis. Present studies indicate that Shen deficiency shares a common disorder characterized by dysfunction of hypothalamic-pituitary-adrenal (HPA) axis. HPA axis may be an important regulator of bone diseases with abnormal homeostasis. Therefore, we posit the existence of hypothalamic-pituitary-adrenal-osteo-related cells axis: cells that comprise bone tissue (osteo-related cells) are targets under the regulation of HPA axis in disorder of bone homeostasis. Chinese herbs for nourishing Shen have potential in the development of treatments for disorder of bone homeostasis.
KeywordsChinese medicine Shen (Kidney) controlling bones hypothalamic-pituitary-adrenal axis bone homeostasis osteoporosis
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- 1.Malenka RC, Nestler EJ, Hyman SE eds. Neural and neuroendocrine control of the internal milieu. In: Molecular neuropharmacology: a foundation for clinical neuroscience. 2nd ed. New York: McGraw-Hill Medical, 246:248–259.Google Scholar
- 9.Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre-and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005;16:1263–1271.CrossRefPubMedGoogle Scholar
- 15.Ren YB, Huang JH, Cai WJ, Shen ZY. Shen-Jing as a Chinese medicine concept might be a counterpart of stem cells in regenerative medicine. Chin J Integr Med 2015 Jul 4. Epub ahead print.Google Scholar