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Study on analgesic effect of traditional Chinese medicine

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Abstract

Chinese medicine has been used in treating pain for a long time. Much progress has been made in studies on the mechanism of the analgesic effect of Chinese medicine in animal experiments. It is found that the analgesic action may be related to the following actions: (1) Reducing the secretion of peripheral algogenic substances and inducing the secretion of pain-sensitive substances; (2) Alleviating the accumulation of local algogenic substances; (3) Increasing the release of endogenous analgesic substances; (4) Regulating c-fos gene and increasing the secretion of such substances in the central nervous system, etc. In this paper, the experimental methods and analgesic effect of Chinese medicines are reviewed.

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References

  1. Xin HW, Shi XY, Luo X, et al. Pharmacodynamic action of Dian-xue-gao. Tradit Chin Drug Res Clin Pharmacol (Chin) 2000;11(5): 281–283.

    Google Scholar 

  2. Liu YQ, Chen H, Li CH. Study on analgesic effect of Chinese traditional medicine Ai Zheng Zhen Tong San. Chin J Comp Med (Chin) 2003;13(5):288–290.

    Google Scholar 

  3. Zhou J, Fang SP, Qi Y, et al. Effect of Gegen Decoction on inflammatory media in joint of adjuvant arthritis rats. Chin J Exp Tradit Med Formul (Chin) 2001;7(3):29–31.

    Google Scholar 

  4. Yang MM, Tong L, Chen YR. Experimental study on analgesic effect and anti-inflammatory effect of ethanol extraction of Dulcamara. Chin Arch Tradit Chin Med (Chin) 2005;23(1):51–54.

    Google Scholar 

  5. Wu X, Chen DH, Lei L, et al. Anti-infalmmation and analgesic effects of Panax japonicus. Pharmacol Clin Chin Materia Med (Chin) 2007;23(1):43–45.

    CAS  Google Scholar 

  6. Tang CP, Jiang T, Gong MJ, et al. The study on the analgesic effects and mechanism of the Tongfengling capsules. J Guangdong Coll Pharm (Chin) 2007;23(3):301–303.

    Google Scholar 

  7. Zhou XS, Yi DB. Studied on the analegsic and anti-inflammatory effects of Clematis Chinensis Osbeck in mice and rats. Chin Clin Med (Chin) 2003; 15(4):12–13.

    Google Scholar 

  8. Liu L, Zhu QS, Wang LM, et al. Anti-inflammation and analegsia compound Weilingxian mixture. Heilongjiang Med Pharm (Chin) 2004;27(1):22–23.

    Google Scholar 

  9. Schwei MJ, Honore P, Rogers SD, et al. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci 1999;19:10886–10897.

    PubMed  CAS  Google Scholar 

  10. Wacnik PW, Eikmeier LJ, Ruggles TR, et al. Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain. J Neurosci 2001;21:9355–9366.

    PubMed  CAS  Google Scholar 

  11. Sarlak A, Gundes H, Ozkurkcugil C, et al. Solitary calcaneal metastasis in superfi cial bladder carcinoma. Int J Clin Pract 2000; 54: 681–682.

    PubMed  CAS  Google Scholar 

  12. Medhurst SJ, Walker K, Bowes M, et al. A rat model of bone cancer pain. Pain 2002; 96: 129–140.

    Article  PubMed  CAS  Google Scholar 

  13. Xiang HB, Yang H, An K, et al. Pathological mechanisms of pain related and model of bone cancer pain. J Clin Anesthesiol (Chin) 2005; 21(5):350–352.

    Google Scholar 

  14. Cain DM, Wacnik PW, Simone DA. Animal models of cancer pain may reveal novel approaches to palliative care. Pain 2001;91: 1–4.

    Article  PubMed  CAS  Google Scholar 

  15. Yu S, Mao-ying QL, Wei PK, et al. Tongluo Sanjie Tincture relieves inflammatory and bone cancer pain in rats: an observation of outcome. Acad J Sec Milit Med Univ (Chin) 2006;27(6):684–686.

    Google Scholar 

  16. Ma WL, Zhang WB. Dialectical thinking of the mechanism of pain and analgesia. Med Philos (Chin) 2002;256(9):46–47.

    Google Scholar 

  17. Zhao ZQ. Pain and the spinal cord. 1st ed. Shanghai: Shanghai Scientific and Technical Publishers, 2000:22–40.

    Google Scholar 

  18. Jia YJ, Sun YY, Miao FL, et al. Intervention by Hua-Jian-Ba-Du membrane on cancer pain and its analgesic mechanisms. Tianjin J Tradit Chin Med (Chin) 2005; 22(2):135.

    Google Scholar 

  19. Ye HY, Xiong XQ, Wang ZP, et al. A study on the anagesic effect of Daphne Odora Var. Marginata Extract. J Gannan Med Coll (Chin) 2004;24(5):505–507.

    Google Scholar 

  20. Sun GC, Yu XF, Li DY. Compound Xiqiancao (siegesbeckiae) capsule on content of IL-1β, IL-8 in rats’ inflammatory articulus caused by sodium urate. World J Integr Tradit West Med (Chin) 2007;2(6): 329–331.

    Google Scholar 

  21. Heng XP, Zhang GH. Experimental study on analgesic effect of Insects Tongluo. Hunan Guiding J Tradit Chin Med Pharm (Chin) 1995; 1(1):33–36.

    Google Scholar 

  22. Nie H, Shen YJ, Zeng N, et al. Mechanism of essential oil of Radix Angelicae dahuricae (EOAD) on neural transmitter of pain model of rats. Pharmacol Clin Chin Materia Med (Chin) 2002;18(3):11–14.

    Google Scholar 

  23. Zhou B. Studying the relive pain function of Bidens Bipinnata L. Modern Chin Med (Chin) 2007;9(2):21–22.

    Google Scholar 

  24. Qin L, Peng X, Zhang SH, et al. Influence of monkshood root-peony root combination on infl amation-induced agents and free radicals. China J Chin Materia Med (Chin) 2000; 25(6):370–373.

    Google Scholar 

  25. Yan SQ, Wu SQ, Feng LY, et al. Mechanism for analgesic actions of Shaoyao Gancao Decoction. J Anhui Tradit Chin Med Coll (Chin) 2001; 20(6):42–44.

    Google Scholar 

  26. Xu JY, Wang FQ, Zheng WF, et al. Influence of Jin-Tie-Suo on pain threshold and NO/NOS in serum of experimental mice. Chin Arch Tradit Chin Med (Chin) 2004;22(1):82–84.

    Google Scholar 

  27. Meng MH, Ren QH, Ma CH, et al. Influence of Ai-tong-ke on microcirculation and lipid peroxide and the superoxide dismutase. Chin J Cancer Prev Treat (Chin) 2002;9(5):553.

    Google Scholar 

  28. Lu F, Ren QH, Wang Li, et al. Clinical and experimental studies on Chinese medicine “Aitongke”. China Cancer 2004;13(5):325–326.

    Google Scholar 

  29. Zhang SF, Shen X, Wu JY, et al. Effects of Yangxueqingnao Granule on analgesia and cerebral blood flow. Chin J ExpTradit Med Formul (Chin) 2007;13(1):44–45,48.

    CAS  Google Scholar 

  30. Xiong YJ, Liu MJ, Liu F. Activating blood circulation to dissipate blood stasis and analgesic and anti-inflammatory of Compound Dragon’s blood liniment. Pharm Clin Chin Materia Med (Chin) 1999;15(3):30–32.

    Google Scholar 

  31. Li XZ, Li H, Ju DY, et al. Pharmacological research on analgesic effect of Gutongling ointment. J Jilin Univ (Med Ed) (Chin) 2004;30(2):201–203.

    Google Scholar 

  32. Fu X. Endogenous opioid peptide-study progress. For Med Sci: Sec Pharmacy (Chin) 2003; 30(6):339–344.

    Google Scholar 

  33. Jiang XJ, Chen ME, Ju YF, et al. Experimental study on the analgesic efficacy of Tong-Mo-Ning. Chin J Pain Med (Chin) 1996; 2(1):23–25.

    Google Scholar 

  34. Dang HZ, Teng JX, Peng ZP, et al. Research on analgesia efect of Jiuqiniantong Capsule. Pract J Med Pharm (Chin) 2003;20(8):592–595.

    Google Scholar 

  35. Lu GW. Peripheral nociceptive receptors in regulation of transcriptional. Progr Physiol Sci 2000;31(2):161–162.

    CAS  Google Scholar 

  36. Han X, Liu W, Qiu DW, et al. Study on analgesic effect of Duliang Pill extract and its effect on c-fos gene expression of periphery tissue. Chin J Exp Tradit Med Formul (Chin) 2003;9(4):34–36.

    Google Scholar 

  37. Hu YB, Zhang YF, Xu JY, et al. Influence of Compound Tall Gastrodia Tuber Agent on central neurotransmitter and catecholamines. Acad Periodic Changchun Coll Tradit Chin Med (Chin) 2003; 19 (4): 39–41.

    Google Scholar 

  38. Niu HM. Clinical and experimental study of Ai-Tong-Xin nasal drop on cancer pain. J Shandong Univ Tradit Chin Med (Chin) 1999;23(6):432–433.

    Google Scholar 

  39. Fu JR, Xu F. Study on mechanism of “Neiyixiao” relieving pelvic pain for endometriosis. Shanghai J Tradit Chin Med (Chin) 1998;32(10): 40–42.

    Google Scholar 

  40. Wang KX, Bi MG. Analgesic effect and mechanism of Tianxiedingtong san in rats. Heilongjiang Med Pharm (Chin) 2001;24(6):13–14.

    Google Scholar 

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Correspondence to Pin-kang Wei  (魏品康).

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Yu, S., Xu, L., Wei, Pk. et al. Study on analgesic effect of traditional Chinese medicine. Chin. J. Integr. Med. 14, 151–156 (2008). https://doi.org/10.1007/s11655-008-0151-z

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  • DOI: https://doi.org/10.1007/s11655-008-0151-z

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