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Trattamento delle lesioni ossee traumatiche con le BMPs: revisione della letteratura

Treatment of traumatic bone injuries with BMPs: a review of the literature

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LO SCALPELLO-OTODI Educational

Abstract

The treatment of open fractures and fracture non-unions is a challenging situation for the orthopaedic surgeon. The use of bone morphogenetic proteins (BMPs) in the treatment of these injuries has been assessed by several authors. Indicated for the treatment of open tibial fractures treated with intramedullary fixation and for the treatment of tibial long-bone non-union, BMPs nowadays have been tested in other anatomical sites. Although the clinical efficacy in these cases has not been demonstrated definitely, the use of BMPs has also been considered on the basis of its high cost. This review summarises the evidence present in the literature on BMPs for the treatment of open fractures and non-unions.

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Authors and Affiliations

  1. U.O. Clinica Ortopedica CTO, Azienda Socio Sanitaria Territoriale Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Università degli Studi di Milano, Milano, Italia

    Jacopo Tamini

  2. Dipartimento di Biotecnologie e Scienze della Vita (DBSV), Università degli Studi dell’Insubria, Varese, Italia

    Jacopo Tamini, Michael Mazzacane, Roberto Marin, Federico Fazzari, Placido Stissi & Davide Pin

  3. Dipartimento di Medicina e di Scienze della Salute ‘Vincenzo Tiberio’, Università degli Studi del Molise, Campobassso, Italia

    Biagio Tangredi & Mario Ronga

  4. Dipartimento di Ortopedia e Traumatologia, Azienda Ospedaliera Papa Giovanni XXIII Bergamo, Bergamo, Italia

    Giorgio Zappalà

  5. U.O. Ortopedia e Traumatologia, Istituto Clinico Città Studi di Milano, Milano, Italia

    Nicolò Castelnuovo

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  1. Jacopo Tamini
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  8. Giorgio Zappalà
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Correspondence to Mario Ronga.

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Conflitto di interesse

Gli autori Jacopo Tamini, Biagio Tangredi, Michael Mazzacane, Roberto Marin, Federico Fazzari, Placido Stissi, Davide Pin, Giorgio Zappalà, Nicolò Castelnuovo, Ronga Mario dichiarano di non avere alcun conflitto di interesse.

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Tamini, J., Tangredi, B., Mazzacane, M. et al. Trattamento delle lesioni ossee traumatiche con le BMPs: revisione della letteratura. LO SCALPELLO 33, 289–296 (2019). https://doi.org/10.1007/s11639-019-00334-y

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