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Innesti di cellule staminali mesenchimali nelle grandi perdite di sostanza

The use of mesenchymal stem cells in severe bone loss

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LO SCALPELLO-OTODI Educational

Abstract

Severe bone loss is a critical issue in trauma and it requires complex techniques to preserve limb form and function. Regenerative medicine, using stem cells and molecular biology, might be useful to enhance bone healing in severe bone loss. Between 2017 and 2018, 4 patients showed severe bone loss. In all of them, the use of stem cells was added to fixation with a cortical graft. Fracture healing occurred in a range of 3 to 8 months. In our experience, the use of stem cells, in association with bone graft and stable fixation, was able to achieve bone healing even in case of severe bone loss.

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Authors and Affiliations

  1. U.O. Ortopedia, D.A.I. di Ortopedia, Riabilitazione e Odontoiatria, A.O.U. Università degli Studi della Campania “Luigi Vanvitelli”, Napoli, Italia

    G. Toro, C. Di Fino, A. De Cicco, A. Braile, F. Lepore & A. Schiavone Panni

  2. Dipartimento di scienze cliniche e medicina traslazionale, Università degli Studi di Roma “Tor Vergata”, Roma, Italia

    G. Toro

  3. U.O.C. Ortopedia e Traumatologia, Ospedale “Villa Malta”, Sarno, Italia

    L. Prinzo, M. Gison & A. Toro

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  1. G. Toro
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  2. L. Prinzo
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  3. M. Gison
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  4. C. Di Fino
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  5. A. De Cicco
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  6. A. Braile
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  7. F. Lepore
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  8. A. Toro
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  9. A. Schiavone Panni
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Corresponding author

Correspondence to A. Toro.

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Conflitto di interesse

Gli autori G. Toro, L. Prinzo, M. Gison, C. Di Fino, A. De Cicco, A. Braile, F. Lepore, A. Toro e A. Schiavone Panni dichiarano di non aver alcun conflitto d’interesse.

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Toro, G., Prinzo, L., Gison, M. et al. Innesti di cellule staminali mesenchimali nelle grandi perdite di sostanza. LO SCALPELLO 33, 258–263 (2019). https://doi.org/10.1007/s11639-019-00331-1

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  • DOI: https://doi.org/10.1007/s11639-019-00331-1

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