Skip to main content

Advertisement

Log in

L’osteogenesi riparativa

Reparative osteogenesis

  • Aggiornamenti
  • Published:
LO SCALPELLO-OTODI Educational

Abstract

Bone healing of diaphyseal fractures is a complex biological process that involves different pathways. Direct healing needs rigid internal fixation, whereas indirect healing occurs in relative stability fixation techniques. There are many biological and mechanical factors that may influence the healing process. In order to provide the best treatment for each fracture, full knowledge of these factors is mandatory for the orthopaedic surgeon.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Bibliografia

  1. Brookes M (1967) The osseous circulation. Biomed Engin 2:294

  2. Rhinelander FW (1968) The normal microcirculation of diaphyseal cortex and its response to fracture. J Bone Jt Surg 50A:784

    Article  Google Scholar 

  3. Marsell R, Einhorn TA (2011) Emerging bone healing therapies. Injury 42(6):551–555

    Article  PubMed  PubMed Central  Google Scholar 

  4. Shapiro F (1988) Cortical bone repair. The relationship of the lacunar-canalicular system and intercellular gap junctions to the repair process. J Bone Jt Surg Am 70(7):1067–1081

    Article  CAS  Google Scholar 

  5. Rahn BA (2002) Bone healing: histologic and physiologic concepts. In: Fackelman GE (ed) Bone in clinical orthopedics. Thieme, Stuttgart, pp 287–326

    Google Scholar 

  6. Schenk RK, Hunziker EB (1994) Histologic and ultrastructural features of fracture healing. In: Brighton CT, Friedlander GE, Lane JM (eds) Bone formation and repair. American Academy of Orthopedic Surgeons, Rosemont, pp 117–145

    Google Scholar 

  7. Gerstenfeld LC, Alkhiary YM, Krall EA et al. (2006) Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem 54(11):1215–1228

    Article  CAS  PubMed  Google Scholar 

  8. Gerstenfeld LC, Cullinane DM, Barnes GL et al. (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88(5):873–884

    Article  CAS  PubMed  Google Scholar 

  9. Cho TJ, Gerstenfeld LC, Einhorn TA (2002) Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 17(3):513–520

    Article  CAS  PubMed  Google Scholar 

  10. Bais MV, Wigner N, Young M et al. (2009) BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone 45(2):254–266

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Calori GM, Albisetti W, Agus A et al. (2007) Risk factors contributing to fracture non-unions. Injury 38:S11–S18

    Article  PubMed  Google Scholar 

  12. Manigrasso MB, O’Connor JP (2008) Comparison of fracture healing among different inbred mouse strains. Calcif Tissue Int 82(6):465–474

    Article  CAS  PubMed  Google Scholar 

  13. Jepsen KJ, Price C, Silkman LJ, Nicholls FH, Nasser P, Hu B, Hadi N, Alapatt M, Stapleton SN, Kakar S, Einhorn TA, Gerstenfeld LC (2008) Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. J Bone Miner Res 23(8):1204–1216

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Simpson CM, Calori GM, Giannoudis PV (2012) Diabetes and fracture healing: the skeletal effects of diabetic drugs. Expert Opin Drug Saf 11(2):215–220

    Article  CAS  PubMed  Google Scholar 

  15. Adam CL, Kenting JF, Court-Brown CM (2001) Cigarette smoking and open tibial fractures. Injury 32:61–65

    Article  Google Scholar 

  16. Ziran B, Cheung S, Smith W, Westerheide K (2005) Comparative efficacy of two different demineralised bone matrix allograft in treating long-bone nonunions in heavy tobacco smokers. Am J Orthop 34(7):329–332

    PubMed  Google Scholar 

  17. Nikolaou VS, Efstathopoulos N, Kontakis G et al. (2009) The influence of osteoporosis in femoral fracture healing time. Injury 40:663–668

    Article  PubMed  Google Scholar 

  18. Perren SM (1979) Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res 138:175–196

    Google Scholar 

  19. Augat P, Margevicius K, Simon J et al. (1998) Local tissue properties in bone healing: influence of size and stability of the osteotomy gap. J Bone Jt Surg 16:475–481

    CAS  Google Scholar 

  20. Wolff J (1892) Das Gesetz der Transformation der Knochen. A Hirschwald, Berlin

    Google Scholar 

  21. Sarmiento A, Latta L (2006) The evolution of functional bracing of fractures. J Bone Jt Surg Br 88(2):141–148

    Article  CAS  Google Scholar 

  22. Biggi F (2002) The biology of fracture healing as related to intramedullary locked nailing. In: Kempf I, Leung JS (eds) Practice of intramedullary locked nails. Springer, Berlin, pp 5–10

    Chapter  Google Scholar 

  23. Perren S (1987) Biomechanics of intramedullary nailing. In: Browner BD (ed) The science and practice of intramedullary nailing. Lea & Febiger, Philadelphia, pp 67–75

    Google Scholar 

  24. Penzkofer R, Maier M, Nolte A, Augat P et al. (2009) Influence of intramedullary nail diameter and locking mode on the stability of tibial shaft fracture fixation. Arch Orthop Trauma Surg 129:525–531

    Article  PubMed  Google Scholar 

  25. Kessler SB, Hallfeldt KK, Perren SM, Schweiberer L (1986) The effects of reaming and intramedullary nailing on fracture healing. Clin Orthop Relat Res 212:18–25

    Google Scholar 

  26. Tigani D, Fravisini M, Stagni C et al. (2005) Interlocking nail for femoral shaft fractures: is dynamization always necessary? Int Orthop 29(2):101–104

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Perren S (2002) Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Jt Surg Br 84-B:1093–1110

    Article  Google Scholar 

  28. Gautier E, Perren S, Cordey J (2000) Strain distribution in plated and unplated sheep tibia. An in vivo experiment. Injury 31:SC37–SC44

    Article  Google Scholar 

  29. Ruedi TP, Murphy WM (2000) AO principles of fracture management. Thieme, Stuttgart

    Google Scholar 

  30. Moss DP, Tejwani N (2007) Biomechanics of external fixation: a review of the literature. Bull NYU Hosp Joint Dis 65(4):294–299

    Google Scholar 

  31. Aro H, Kelly P, Lewallen D, Chao E (1990) The effects of physiologic dynamic compression on bone healing under external fixation. Clin Orthop 256:260–273

    Google Scholar 

  32. Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38(4):S3–S6

    Article  Google Scholar 

  33. Urist MR, Silverman BF, Buring K (1967) The bone induction principle. Clin Orthop Relat Res 53:243–283

    Article  CAS  PubMed  Google Scholar 

  34. Friedlaender GE, Perry CR, Cole JD et al. (2001) Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Jt Surg Am 83-A(Suppl 1 Pt 2):S151–158

    Google Scholar 

  35. Goldhahn J, Scheele WH, Mitlak BH et al. (2008) Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis. Bone 43(2):343–347

    Article  PubMed  Google Scholar 

  36. Aspenberg P, Genant HK, Johansson T et al. (2010) Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 25(2):404–414

    Article  CAS  PubMed  Google Scholar 

  37. Li YF, Luo E, Feng G et al. (2010) Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporos Int 21:1889–1897

    Article  CAS  PubMed  Google Scholar 

  38. Li YF, Zhou CC, Li JH et al. (2012) The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats. Osteoporos Int 23(4):1463–1474

    Article  CAS  PubMed  Google Scholar 

  39. Brandi ML (2013) Healing of the bone with anti-fracture drugs. Expert Opin Pharmacother 14(11):1441–1447

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. Capone.

Ethics declarations

Conflitto di interessi

Gli autori Antonio Capone, Giuseppe Marongiu e Rossella Sirianni dichiarano di non aver alcun conflitto d’interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and animal rights

L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Capone, A., Marongiu, G. & Sirianni, R. L’osteogenesi riparativa. LO SCALPELLO 29, 2–9 (2015). https://doi.org/10.1007/s11639-015-0106-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11639-015-0106-z

Navigation