Advertisement

LO SCALPELLO-OTODI Educational

, Volume 29, Issue 1, pp 2–9 | Cite as

L’osteogenesi riparativa

Aggiornamenti
  • 137 Downloads

Reparative osteogenesis

Abstract

Bone healing of diaphyseal fractures is a complex biological process that involves different pathways. Direct healing needs rigid internal fixation, whereas indirect healing occurs in relative stability fixation techniques. There are many biological and mechanical factors that may influence the healing process. In order to provide the best treatment for each fracture, full knowledge of these factors is mandatory for the orthopaedic surgeon.

Notes

Conflitto di interessi

Gli autori Antonio Capone, Giuseppe Marongiu e Rossella Sirianni dichiarano di non aver alcun conflitto d’interesse.

Consenso informato e conformità agli standard etici

Tutte le procedure descritte nello studio e che hanno coinvolto esseri umani sono state attuate in conformità alle norme etiche stabilite dalla dichiarazione di Helsinki del 1975 e successive modifiche. Il consenso informato è stato ottenuto da tutti i pazienti inclusi nello studio.

Human and animal rights

L’articolo non contiene alcuno studio eseguito su esseri umani e su animali da parte degli autori.

Bibliografia

  1. 1.
    Brookes M (1967) The osseous circulation. Biomed Engin 2:294 Google Scholar
  2. 2.
    Rhinelander FW (1968) The normal microcirculation of diaphyseal cortex and its response to fracture. J Bone Jt Surg 50A:784 CrossRefGoogle Scholar
  3. 3.
    Marsell R, Einhorn TA (2011) Emerging bone healing therapies. Injury 42(6):551–555 CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Shapiro F (1988) Cortical bone repair. The relationship of the lacunar-canalicular system and intercellular gap junctions to the repair process. J Bone Jt Surg Am 70(7):1067–1081 CrossRefGoogle Scholar
  5. 5.
    Rahn BA (2002) Bone healing: histologic and physiologic concepts. In: Fackelman GE (ed) Bone in clinical orthopedics. Thieme, Stuttgart, pp 287–326 Google Scholar
  6. 6.
    Schenk RK, Hunziker EB (1994) Histologic and ultrastructural features of fracture healing. In: Brighton CT, Friedlander GE, Lane JM (eds) Bone formation and repair. American Academy of Orthopedic Surgeons, Rosemont, pp 117–145 Google Scholar
  7. 7.
    Gerstenfeld LC, Alkhiary YM, Krall EA et al. (2006) Three-dimensional reconstruction of fracture callus morphogenesis. J Histochem Cytochem 54(11):1215–1228 CrossRefPubMedGoogle Scholar
  8. 8.
    Gerstenfeld LC, Cullinane DM, Barnes GL et al. (2003) Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88(5):873–884 CrossRefPubMedGoogle Scholar
  9. 9.
    Cho TJ, Gerstenfeld LC, Einhorn TA (2002) Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 17(3):513–520 CrossRefPubMedGoogle Scholar
  10. 10.
    Bais MV, Wigner N, Young M et al. (2009) BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells. Bone 45(2):254–266 CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Calori GM, Albisetti W, Agus A et al. (2007) Risk factors contributing to fracture non-unions. Injury 38:S11–S18 CrossRefPubMedGoogle Scholar
  12. 12.
    Manigrasso MB, O’Connor JP (2008) Comparison of fracture healing among different inbred mouse strains. Calcif Tissue Int 82(6):465–474 CrossRefPubMedGoogle Scholar
  13. 13.
    Jepsen KJ, Price C, Silkman LJ, Nicholls FH, Nasser P, Hu B, Hadi N, Alapatt M, Stapleton SN, Kakar S, Einhorn TA, Gerstenfeld LC (2008) Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. J Bone Miner Res 23(8):1204–1216 CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Simpson CM, Calori GM, Giannoudis PV (2012) Diabetes and fracture healing: the skeletal effects of diabetic drugs. Expert Opin Drug Saf 11(2):215–220 CrossRefPubMedGoogle Scholar
  15. 15.
    Adam CL, Kenting JF, Court-Brown CM (2001) Cigarette smoking and open tibial fractures. Injury 32:61–65 CrossRefGoogle Scholar
  16. 16.
    Ziran B, Cheung S, Smith W, Westerheide K (2005) Comparative efficacy of two different demineralised bone matrix allograft in treating long-bone nonunions in heavy tobacco smokers. Am J Orthop 34(7):329–332 PubMedGoogle Scholar
  17. 17.
    Nikolaou VS, Efstathopoulos N, Kontakis G et al. (2009) The influence of osteoporosis in femoral fracture healing time. Injury 40:663–668 CrossRefPubMedGoogle Scholar
  18. 18.
    Perren SM (1979) Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res 138:175–196 Google Scholar
  19. 19.
    Augat P, Margevicius K, Simon J et al. (1998) Local tissue properties in bone healing: influence of size and stability of the osteotomy gap. J Bone Jt Surg 16:475–481 Google Scholar
  20. 20.
    Wolff J (1892) Das Gesetz der Transformation der Knochen. A Hirschwald, Berlin Google Scholar
  21. 21.
    Sarmiento A, Latta L (2006) The evolution of functional bracing of fractures. J Bone Jt Surg Br 88(2):141–148 CrossRefGoogle Scholar
  22. 22.
    Biggi F (2002) The biology of fracture healing as related to intramedullary locked nailing. In: Kempf I, Leung JS (eds) Practice of intramedullary locked nails. Springer, Berlin, pp 5–10 CrossRefGoogle Scholar
  23. 23.
    Perren S (1987) Biomechanics of intramedullary nailing. In: Browner BD (ed) The science and practice of intramedullary nailing. Lea & Febiger, Philadelphia, pp 67–75 Google Scholar
  24. 24.
    Penzkofer R, Maier M, Nolte A, Augat P et al. (2009) Influence of intramedullary nail diameter and locking mode on the stability of tibial shaft fracture fixation. Arch Orthop Trauma Surg 129:525–531 CrossRefPubMedGoogle Scholar
  25. 25.
    Kessler SB, Hallfeldt KK, Perren SM, Schweiberer L (1986) The effects of reaming and intramedullary nailing on fracture healing. Clin Orthop Relat Res 212:18–25 Google Scholar
  26. 26.
    Tigani D, Fravisini M, Stagni C et al. (2005) Interlocking nail for femoral shaft fractures: is dynamization always necessary? Int Orthop 29(2):101–104 CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Perren S (2002) Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Jt Surg Br 84-B:1093–1110 CrossRefGoogle Scholar
  28. 28.
    Gautier E, Perren S, Cordey J (2000) Strain distribution in plated and unplated sheep tibia. An in vivo experiment. Injury 31:SC37–SC44 CrossRefGoogle Scholar
  29. 29.
    Ruedi TP, Murphy WM (2000) AO principles of fracture management. Thieme, Stuttgart Google Scholar
  30. 30.
    Moss DP, Tejwani N (2007) Biomechanics of external fixation: a review of the literature. Bull NYU Hosp Joint Dis 65(4):294–299 Google Scholar
  31. 31.
    Aro H, Kelly P, Lewallen D, Chao E (1990) The effects of physiologic dynamic compression on bone healing under external fixation. Clin Orthop 256:260–273 Google Scholar
  32. 32.
    Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38(4):S3–S6 CrossRefGoogle Scholar
  33. 33.
    Urist MR, Silverman BF, Buring K (1967) The bone induction principle. Clin Orthop Relat Res 53:243–283 CrossRefPubMedGoogle Scholar
  34. 34.
    Friedlaender GE, Perry CR, Cole JD et al. (2001) Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Jt Surg Am 83-A(Suppl 1 Pt 2):S151–158 Google Scholar
  35. 35.
    Goldhahn J, Scheele WH, Mitlak BH et al. (2008) Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis. Bone 43(2):343–347 CrossRefPubMedGoogle Scholar
  36. 36.
    Aspenberg P, Genant HK, Johansson T et al. (2010) Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 25(2):404–414 CrossRefPubMedGoogle Scholar
  37. 37.
    Li YF, Luo E, Feng G et al. (2010) Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporos Int 21:1889–1897 CrossRefPubMedGoogle Scholar
  38. 38.
    Li YF, Zhou CC, Li JH et al. (2012) The effects of combined human parathyroid hormone (1-34) and zoledronic acid treatment on fracture healing in osteoporotic rats. Osteoporos Int 23(4):1463–1474 CrossRefPubMedGoogle Scholar
  39. 39.
    Brandi ML (2013) Healing of the bone with anti-fracture drugs. Expert Opin Pharmacother 14(11):1441–1447 CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2015

Authors and Affiliations

  1. 1.Clinica Ortopedica e TraumatologicaUniversità degli Studi di CagliariCagliariItalia

Personalised recommendations