Genetic Risk Factors for Diverticular Disease—Emerging Evidence

Abstract

Diverticular disease is traditionally understood as an environmental disease caused by diet and constipation. However, genes are increasing understood to play a role in pathogenesis. Twin studies suggest a substantial component of individual risk is due to heritable factors. Association of diverticular disease with other traits suggests an underlying biological mechanism and recently genome-wide association studies have described the genetic architecture underlying this complex phenotype. These studies suggest a new paradigm for understanding this common surgical disease.

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Correspondence to Lillias H. Maguire.

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Maguire, L.H. Genetic Risk Factors for Diverticular Disease—Emerging Evidence. J Gastrointest Surg (2020). https://doi.org/10.1007/s11605-020-04693-5

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Keywords

  • Diverticulitis
  • Ehlers-Danlos syndrome
  • Diverticulosis