The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms

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Supported by the National Natural Science Foundation of China (Nos. 81770539 and 81572428), the National key research and development program of China (No. 2017YFC0110003), and the Guangzhou Science and Technology Plan (201804010078). The funding body had no part in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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Huiying Shi, Luohai Chen, and Lingjun Meng contributed equally to this work. R.L. and J.C designed and supervised the study and data analysis; H.S., L.C., and L.M. performed most of data collection, analysis, and wrote the manuscript; Q.Z and Y.L. provided pathological assessment and analysis.

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Correspondence to Rong Lin or Jie Chen.

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Shi, H., Chen, L., Meng, L. et al. The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms. J Gastrointest Surg (2020).

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  • Gastroenteropancreatic neuroendocrine neoplasms
  • Classification
  • Ki-67 index
  • Grade 3 gastric neuroendocrine tumors (G3 g-NETs)
  • Prognostic factors