The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms

This is a preview of subscription content, log in to check access.

Fig. 1

References

  1. 1.

    Lloyd RV OR, Klöppel G, Rosai J.: WHO classification of tumours of endocrine organs. Lyon: IARC Press; 2017.

    Google Scholar 

  2. 2.

    Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA, Board WHOCoTE: The 2019 WHO classification of tumours of the digestive system. Histopathology 2020, 76(2):182–188.

    Article  Google Scholar 

  3. 3.

    Brims FJ, Meniawy TM, Duffus I, de Fonseka D, Segal A, Creaney J, Maskell N, Lake RA, de Klerk N, Nowak AK: A Novel Clinical Prediction Model for Prognosis in Malignant Pleural Mesothelioma Using Decision Tree Analysis. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer 2016, 11(4):573–582.

    Article  Google Scholar 

  4. 4.

    Lu Y, Liu L, Luan S, Xiong J, Geng D, Yin B: The diagnostic value of texture analysis in predicting WHO grades of meningiomas based on ADC maps: an attempt using decision tree and decision forest. Eur Radiol 2019, 29(3):1318–1328.

    Article  Google Scholar 

Download references

Funding

Supported by the National Natural Science Foundation of China (Nos. 81770539 and 81572428), the National key research and development program of China (No. 2017YFC0110003), and the Guangzhou Science and Technology Plan (201804010078). The funding body had no part in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Author information

Affiliations

Authors

Contributions

Huiying Shi, Luohai Chen, and Lingjun Meng contributed equally to this work. R.L. and J.C designed and supervised the study and data analysis; H.S., L.C., and L.M. performed most of data collection, analysis, and wrote the manuscript; Q.Z and Y.L. provided pathological assessment and analysis.

Corresponding authors

Correspondence to Rong Lin or Jie Chen.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Shi, H., Chen, L., Meng, L. et al. The Role of Ki-67 Index Cut-off of 55% and Differentiation in Redefining NET and NEC for Grade 3 Gastrointestinal Neuroendocrine Neoplasms. J Gastrointest Surg (2020). https://doi.org/10.1007/s11605-020-04651-1

Download citation

Keywords

  • Gastroenteropancreatic neuroendocrine neoplasms
  • Classification
  • Ki-67 index
  • Grade 3 gastric neuroendocrine tumors (G3 g-NETs)
  • Prognostic factors