Journal of Gastrointestinal Surgery

, Volume 23, Issue 2, pp 339–347 | Cite as

Anastomotic Location Predicts Anastomotic Leakage After Elective Colonic Resection for Cancer

  • Thibault VoronEmail author
  • Matthieu Bruzzi
  • Emilia Ragot
  • Franck Zinzindohoue
  • Jean-Marc Chevallier
  • Richard Douard
  • Anne Berger
Original Article



Anastomotic leakage (AL) is a potential feared complication after colorectal resection, which is associated with an increased risk of postoperative mortality and frequently requires additional surgery. The aim of this study was to assess major independent risk factors for AL after elective colonic resection for cancer, including anastomotic location.


Among 1940 consecutive patients referred to our institution for colorectal adenocarcinoma, 1025 patients had elective colonic resection with intraperitoneal anastomosis without diverting stoma. Risk factors were assessed among preoperative, operative, and histological data.


Clinical AL was observed in 36 patients (3.5%) with 24 patients requiring revisional surgery (67%). In multivariate analysis, endoscopic impassable tumor and colo-colic or ileo-colic anastomosis were independent risk factors for AL. The occurrence of AL was associated with poor overall (43.1 months vs. 146.4 months; p < 0.001) and disease-free survival (40.5 months vs. 137.3 months; p = 0.003).


Anastomotic leakage occurs more frequently after colo-colic and ileo-colic anastomosis than after intraperitoneal colorectal anastomosis.

The right colectomy appears to be at higher risk of AL, with a greater risk of surgical intervention than after an elective left colectomy. Ileo-colic anastomosis should be avoided in cases of suboptimal conditions.


Colonic resection Colorectal cancer Anastomotic leakage Right colectomy Prognostic factors 


Author Contribution

Study conception and design: Voron, Douard, Berger

Acquisition of data: Voron, Bruzzi, Ragot

Analysis and interpretation of data: Voron, Zinzindohoue, Chevallier, Douard, Berger

Drafting of manuscript: Voron, Douard, Berger

Critical Revision: Voron, Bruzzi, Ragot, Zinzindohoue, Chevallier, Douard, Berger


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Copyright information

© The Society for Surgery of the Alimentary Tract 2018

Authors and Affiliations

  1. 1.Department of General, Digestive and Oncological Surgery, Georges Pompidou European HospitalAP-HP, Assistance Publique-Hôpitaux de ParisParisFrance
  2. 2.Faculté de Médecine Paris DescartesParisFrance

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