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Preoperative Lower Esophageal Sphincter Manometry Data Neither Impact Manifestations of GERD nor Outcome After Laparoscopic Nissen Fundoplication

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

Experience with laparoscopic antireflux surgery (LARS) in patients with gastroesophageal reflux disease (GERD) and manometrically intact lower esophageal sphincter (LES) is limited. The disease pattern may be different and LARS may fail to control reflux or result in higher rates of dysphagia. This is the first study investigating the impact of preoperative LES manometry data not only on manifestations of GERD and subjective outcome alone but also on objective outcomes 1 year after LARS.

Methods

Three hundred fifty-one GERD patients underwent LARS and had subjective symptom and quality of life assessment, upper gastrointestinal endoscopy, barium swallow esophagogram, 24-h esophageal pH monitoring, and manometry pre- and 1 year postoperatively. Patients were divided into those with a preoperatively intact versus defective LES based on intraabdominal length and resting pressure. Baseline and 1-year postoperative follow-up data were compared.

Results

Preoperative manifestations of GERD were similar in each group. Postoperatively, all symptoms except flatulence, quality of life scores, and objective manifestations improved significantly in each group.

Conclusions

The preoperative manometric character of the LES neither impacts the manifestations of GERD nor subjective and objective outcomes after LARS. Patients with GERD and manometrically intact LES have no higher risk for postoperative dysphagia.

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References

  1. Bonatti H, Achem SR, Hinder RA. Impact of changing epidemiology of gastroesophageal reflux disease on its diagnosis and treatment. J Gastrointest Surg 2008;12:373–381.

    Article  PubMed  Google Scholar 

  2. Holloway RH, Kocyan P, Dent J. Provocation of transient lower esophageal sphincter relaxations by meals in patients with symptomatic gastroesophageal reflux. Dig Dis Sci 1991;36(8):1034–1039. doi:10.1007/BF01297443.

    Article  PubMed  CAS  Google Scholar 

  3. Gadenstatter M, Klingler A, Prommegger R, Hinder RA, Wetscher GJ. Laparoscopic partial posterior fundoplication provides excellent intermediate results in GERD patients with impaired esophageal peristalsis. Surgery 1999;126(3):548–552. doi:10.1016/S0039-6060(99)70097-8.

    Article  PubMed  CAS  Google Scholar 

  4. Ciovica R, Gadenstatter M, Klingler A, Lechner W, Riedl O, Schwab GP. Quality of life in GERD patients: Medical treatment versus antireflux surgery. J Gastrointest Surg 2006;10(7):934–939. doi:10.1016/j.gassur.2006.04.001.

    Article  PubMed  Google Scholar 

  5. Wetscher GJ, Glaser K, Gadenstaetter M, Profanter C, Hinder RA. The effect of medical therapy and antireflux surgery on dysphagia in patients with gastroesophageal reflux disease without esophageal stricture. Am J Surg 1999;177(3):189–192. doi:10.1016/S0002-9610(99)00011-2.

    Article  PubMed  CAS  Google Scholar 

  6. Iwakiri K, Tanaka Y, Kawami N, Sano H, Kotoyori M, Sakamoto C. Pathophysiology of gastroesophageal reflux disease: Motility factors. Nippon Rinsho. 2007;65(5):829–835.

    PubMed  Google Scholar 

  7. Bonavina L, Evander A, DeMeester TR, Walther B, Cheng SC, Palazzo L, Concannon JL. Length of the distal esophageal sphincter and competency of the cardia. Am J Surg 1986;151(1):25–34. doi:10.1016/0002-9610(86)90007-3.

    Article  PubMed  CAS  Google Scholar 

  8. Zaninotto G, DeMeester TR, Schwizer W, Johansson KE, Cheng SC. The lower esophageal sphincter in health and disease. Am J Surg 1988;155(1):104–111. doi:10.1016/S0002-9610(88)80266-6.

    Article  PubMed  CAS  Google Scholar 

  9. Cowgill SM, Bloomston M, Al-Saadi S, Villadolid D, Rosemurgy AS 2nd. Normal lower esophageal sphincter pressure and length does not impact outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg 2007;11(6):701–707. doi:10.1007/s11605-007-0152-9.

    Article  PubMed  Google Scholar 

  10. Patti MG, Perretta S, Fisichella PM, D'Avanzo A, Galvani C, Gorodner V, Way LW. Laparoscopic antireflux surgery: Preoperative lower esophageal sphincter pressure does not affect outcome. Surg Endosc 2003;17(3):386–389. doi:10.1007/s00464-002-8934-3.

    Article  PubMed  CAS  Google Scholar 

  11. Ritter MP, Peters JH, DeMeester TR, Crookes PF, Mason RJ, Green L, Tefera L, Bremner CG. Outcome after laparoscopic fundoplication is not dependent on a structurally defective lower esophageal sphincter. J Gastrointest Surg 1998;2(6):567–572. doi:10.1016/S1091-255X(98)80058-9.

    Article  PubMed  CAS  Google Scholar 

  12. Dent J, Dodds WJ, Friedman RH, Sekiguchi T, Hogan WJ, Arndorfer RC, Petrie DJ. Mechanism of gastroesophageal reflux in recumbent asymptomatic human subjects. J Clin Invest 1980;65(2):256–267. doi:10.1172/JCI109667.

    Article  PubMed  CAS  Google Scholar 

  13. Holloway RH, Penagini R, Ireland AC. Criteria for objective definition of transient lower esophageal sphincter relaxation. Am J Physiol 1995;268(1 Pt 1):G128–G133.

    PubMed  CAS  Google Scholar 

  14. Lund RJ, Wetcher GJ, Raiser F, Glaser K, Perdikis G, Gadenstatter M, Katada N, Filipi CJ, Hinder RA. Laparoscopic Toupet fundoplication for gastroesophageal reflux disease with poor esophageal body motility. J Gastrointest Surg 1997;1(4):301–308. discussion 308doi:10.1016/S1091-255X(97)80049-2.

    Article  PubMed  CAS  Google Scholar 

  15. Wieslaw T, Adam K, Artur B, Lech B, Krzysztof B. Nissen fundoplication improves gastric myoelectrical activity characteristics and symptoms in gastroesophageal reflux patients: Evaluation in transcutaneous electrogastrography. Surg Endosc 2008;22:134–140.

    Article  PubMed  Google Scholar 

  16. DeMeester TR, Ireland AP. Gastric pathology as an initiator and potentiator of gastroesophageal reflux disease. Dis Esophagus 1997;10(1):1–8.

    PubMed  CAS  Google Scholar 

  17. Mason RJ, DeMeester TR, Lund RJ, Peters JH, Crookes P, Ritter M, Gadenstatter M, Hagen JA. Nissen fundoplication prevents shortening of the sphincter during gastric distention. Arch Surg 1997;132(7):719–724. discussion 724–716.

    PubMed  CAS  Google Scholar 

  18. DeMeester TR, Bonavina L, Albertucci M. Nissen fundoplication for gastroesophageal reflux disease. Evaluation of primary repair in 100 consecutive patients. Ann Surg 1986;204(1):9–20. doi:10.1097/00000658-198607000-00002.

    Article  PubMed  CAS  Google Scholar 

  19. Hinder RA, Stein HJ, Bremner CG, DeMeester TR. Relationship of a satisfactory outcome to normalization of delayed gastric emptying after Nissen fundoplication. Ann Surg 1989;210(4):458–464. discussion 464–455doi:10.1097/00000658-198910000-00006.

    Article  PubMed  CAS  Google Scholar 

  20. Schwizer W, Hinder RA, DeMeester TR. Does delayed gastric emptying contribute to gastroesophageal reflux disease? Am J Surg 1989;157(1):74–81. doi:10.1016/0002-9610(89)90422-4.

    Article  PubMed  CAS  Google Scholar 

  21. Hinder RA, Filipi CJ, Wetscher G, Neary P, DeMeester TR, Perdikis G. Laparoscopic Nissen fundoplication is an effective treatment for gastroesophageal reflux disease. Ann Surg 1994;220(4):472–481. discussion 481–473doi:10.1097/00000658-199410000-00006.

    Article  PubMed  CAS  Google Scholar 

  22. Johnsson F, Holloway RH, Ireland AC, Jamieson GG, Dent J. Effect of fundoplication on transient lower oesophageal sphincter relaxation and gas reflux. Br J Surg 1997;84(5):686–689. doi:10.1002/bjs.1800840533.

    Article  PubMed  CAS  Google Scholar 

  23. Lundell LR. The knife or the pill in the long-term treatment of gastroesophageal reflux disease? Yale J Biol Med 1994;67(34):233–246.

    PubMed  CAS  Google Scholar 

  24. Lundell L, Miettinen P, Myrvold HE, Pedersen SA, Liedman B, Hatlebakk JG, Julkonen R, Levander K, Carlsson J, Lamm M, Wiklund I. Continued (5-year) follow-up of a randomized clinical study comparing antireflux surgery and omeprazole in gastroesophageal reflux disease. J Am Coll Surg 2001;192(2):172–179. discussion 179–181doi:10.1016/S1072-7515(00)00797-3.

    Article  PubMed  CAS  Google Scholar 

  25. Ciovica R, Gadenstatter M, Klingler A, Neumayer C, Schwab GP. Laparoscopic antireflux surgery provides excellent results and quality of life in gastroesophageal reflux disease patients with respiratory symptoms. J Gastrointest Surg 2005;9(5):633–637. doi:10.1016/j.gassur.2005.02.008.

    Article  PubMed  Google Scholar 

  26. Eypasch E, Williams JI, Wood-Dauphinee S, Ure BM, Schmulling C, Neugebauer E, Troidl H. Gastrointestinal quality of life index: Development, validation and application of a new instrument. Br J Surg 1995;82(2):216–222. doi:10.1002/bjs.1800820229.

    Article  PubMed  CAS  Google Scholar 

  27. Velanovich V, Vallance SR, Gusz JR, Tapia FV, Harkabus MA. Quality of life scale for gastroesophageal reflux disease. J Am Coll Surg 1996;183(3):217–224.

    PubMed  CAS  Google Scholar 

  28. Savary M, Miller G. The esophagus. Handbook and atlas of endoscopy. Switzerland: Gassman, 1978, pp 135–139.

    Google Scholar 

  29. Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L. Endoscopic assessment of oesophagitis: Clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999;45(2):172–180.

    Article  PubMed  CAS  Google Scholar 

  30. DeMeester TR, Wang CI, Wernly JA, Pellegrini CA, Little AG, Klementschitsch P, Bermudez G, Johnson LF, Skinner DB. Technique, indications, and clinical use of 24 hour esophageal pH monitoring. J Thorac Cardiovasc Surg 1980;79(5):656–670.

    PubMed  CAS  Google Scholar 

  31. Galvani C, Fisichella PM, Gorodner MV, Perretta S, Patti MG. Symptoms are a poor indicator of reflux status after fundoplication for gastroesophageal reflux disease: Role of esophageal functions tests. Arch Surg 2003;138(5):514–518. discussion 518–519doi:10.1001/archsurg.138.5.514.

    Article  PubMed  Google Scholar 

  32. Alexander HC, Hendler RS, Seymour NE, Shires GT 3rd. Laparoscopic treatment of gastroesophageal reflux disease. Am Surg 1997;63(5):434–440.

    PubMed  CAS  Google Scholar 

  33. Cole SJ, van den Bogaerde JB, van der Walt H. Preoperative esophageal manometry does not predict postoperative dysphagia following anti-reflux surgery. Dis Esophagus. 2005;18(1):51–56. doi:10.1111/j.1442-2050.2005.00425.x.

    Article  PubMed  CAS  Google Scholar 

  34. Jobe BA, Wallace J, Hansen PD, Swanstrom LL. Evaluation of laparoscopic Toupet fundoplication as a primary repair for all patients with medically resistant gastroesophageal reflux. Surg Endosc 1997;11(11):1080–1083. doi:10.1007/s004649900534.

    Article  PubMed  CAS  Google Scholar 

  35. Karim SS, Panton ON, Finley RJ, Graham AJ, Dong S, Storseth C, Clifton J. Comparison of total versus partial laparoscopic fundoplication in the management of gastroesophageal reflux disease. Am J Surg 1997;173(5):375–378. doi:10.1016/S0002-9610(97)00078-0.

    Article  PubMed  CAS  Google Scholar 

  36. McKernan JB, Champion JK. Minimally invasive antireflux surgery. Am J Surg 1998;175(4):271–276. doi:10.1016/S0002-9610(98)00034-8.

    Article  PubMed  CAS  Google Scholar 

  37. Perdikis G, Hinder RA, Lund RJ, Raiser F, Katada N. Laparoscopic Nissen fundoplication: Where do we stand? Surg Laparosc Endosc 1997;7(1):17–21. doi:10.1097/00019509-199702000-00005.

    Article  PubMed  CAS  Google Scholar 

  38. Fibbe C, Layer P, Keller J, Strate U, Emmermann A, Zornig C. Esophageal motility in reflux disease before and after fundoplication: A prospective, randomized, clinical, and manometric study. Gastroenterology 2001;121(1):5–14. doi:10.1053/gast.2001.25486.

    Article  PubMed  CAS  Google Scholar 

  39. Herron DM, Swanstrom LL, Ramzi N, Hansen PD. Factors predictive of dysphagia after laparoscopic Nissen fundoplication. Surg Endosc 1999;13(12):1180–1183. doi:10.1007/PL00009616.

    Article  PubMed  CAS  Google Scholar 

  40. Blom D, Peters JH, DeMeester TR, Crookes PF, Hagan JA, DeMeester SR, Bremner C. Physiologic mechanism and preoperative prediction of new-onset dysphagia after laparoscopic Nissen fundoplication. J Gastrointest Surg 2002;6(1):22–27. discussion 27–28doi:10.1016/S1091-255X(01)00051-8.

    Article  PubMed  Google Scholar 

  41. Morgenthal CB, Lin E, Shane MD, Hunter JG, Smith CD. Who will fail laparoscopic Nissen fundoplication? Preoperative prediction of long-term outcomes. Surg Endosc 2007;21(11):1978–1984. doi:10.1007/s00464-007-9490-7.

    Article  PubMed  Google Scholar 

  42. Wills VL, Hunt DR. Dysphagia after antireflux surgery. Br J Surg. 2001;88(4):486–499. doi:10.1046/j.1365-2168.2001.01662.x.

    Article  PubMed  CAS  Google Scholar 

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Riedl, O., Gadenstätter, M., Lechner, W. et al. Preoperative Lower Esophageal Sphincter Manometry Data Neither Impact Manifestations of GERD nor Outcome After Laparoscopic Nissen Fundoplication. J Gastrointest Surg 13, 1189–1197 (2009). https://doi.org/10.1007/s11605-009-0890-y

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