Table 3 Comparison of photon chemoradiotherapy, radiotherapy, EGFR-TKI, and CIRT alone for elderly patients with locally advanced NSCLC

From: Carbon-ion radiotherapy for octogenarians with locally advanced non-small-cell lung cancer

Author Median age (years) Stage Treatment No. of patients Median OS (months) Median PFS (months) Most common severe toxicity
(%)
Atagi et al. [18] 77 ΙΙΙ CRT 100 22.4 8.9 Grade ≥ 3 toxicity: leukopenia, 63.5%; thrombocytopenia, 29.2%; infection, 12.5%; radiation pneumonitis, 6.5%; dyspnea, 4.2%
77   RT 100 16.9 6.8 Grade ≥ 3 toxicity: radiation pneumonitis, 5.3%; dyspnea, 5.1%; infection, 4.1%)
Driessen et al. [19] Patients ΙΙΙ CCRT 72 18 NA NA
 ≥ 70   SCRT 52 12
RT 34 11
NCT 58 5
Miller et al. [20] 75.8 ΙΙΙ CRT 18,206 18.1 NA NA
79.4   RT 5023 12.2  
Kim et al. [21] 73.0 ΙΙΙ CCRT 54 21.1 73 Grade ≥ 2 esophagitis, 44.4%; Grade 3–4 radiation pneumonitis, 18.5%
75.2   RT 28 18.1 75 Grade ≥ 2 esophagitis, 17.9%; Grade 3–4 radiation pneumonitis, 14.3%
Corre et al. [17] 83.9 I–IV EGFR-TKI 114 20.9 11.9 Grade ≥ 3 diarrhea, 17.0%; cutaneous, 10.3%; others, 41.0%
Present study 82.0 ΙΙ–ΙΙΙ CIRT 32 33.1 20.8 Grade 3 radiation pneumonitis, 3.1%
(ΙΙΙ)   (15) (22.2) (15.1)
  1. PFS progression-free survival, OS overall survival, CRT chemoradiotherapy, RT radiotherapy, CCRT concurrent chemoradiotherapy, SCRT, sequential chemoradiotherapy, NCT no curative treatment, NA not applicable, EGFR-TKI an epidermal growth factor receptor tyrosine kinase inhibitor, CIRT carbon-ion radiotherapy