Abstract
Purpose
To evaluate the potential usefulness of the balloon-occluded histoacryl glue embolization (B-glue) technique.
Materials and methods
Both flow-dependent (no balloon occlusion) and B-glue techniques were used for 24 intercostal arteries of two female swine. N-butyl 2-cyanoacrylate (NBCA) was diluted with lipiodol to a 50 % solution, which was infused after occluding the arteries with microballoon catheters. The embolization range, fragmentation, reflux, adhesion, and glue particle attachment were compared between flow-dependent and B-glue techniques.
Results
The B-glue technique was performed in a controlled fashion resulting in successful arterial occlusion without fragmented migration of the injected glue cast. Reflux occurred less frequently with the B-glue technique and was significantly different (p = 0.012) from that for the flow-dependent technique. Catheters were safely removed from the arterial walls, although in one instance (8.3 %), large glue particles were found to be attached to the catheter tip on removal. Conversely, the flow-dependent technique was more difficult to control and resulted in several instances of higher rates of fragmentation.
Conclusion
The B-glue technique can efficiently control NBCA delivery with lower rates of reflux.
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Acknowledgment
We would like to express many thanks to Prof. Kenji Takizawa, who first suggested this procedure, and would also like to extend our most sincere gratitude to Terumo Co. Clinical Supply, Gifu, Japan, who kindly provided us with the facility, animals, and ‘Attendant Delta’ microballoon catheters in order to conduct this independent comparative study.
Conflict of interest
The authors disclose that they have no conflicts of interest that could influence this report.
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Hamaguchi, S., Lohman, B.D., Ogawa, Y. et al. Preliminary findings of arterial embolization with balloon-occluded and flow-dependent histoacryl glue embolization in a swine model. Jpn J Radiol 33, 344–351 (2015). https://doi.org/10.1007/s11604-015-0426-1
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DOI: https://doi.org/10.1007/s11604-015-0426-1