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Time-intensity curve in the abdominal aorta on dynamic contrast-enhanced MRI with high temporal and spatial resolution: Gd-EOB-DTPA versus Gd-DTPA in vivo

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Abstract

Purpose

To evaluate the difference in the time-intensity curves (TICs) of the abdominal aorta on dynamic contrast-enhanced MRI (DCE-MRI) between Gd-DTPA and Gd-EOB-DTPA.

Materials and methods

Ten healthy volunteers underwent DCE-MRI three times with the following protocol: group A, Gd-DTPA at an injection rate of 3 ml/s; group B, Gd-EOB-DTPA, 3 ml/s; group C, Gd-EOB-DTPA, 1.5 ml/s. Signal intensities (SIs) of the abdominal aorta were measured, and the contrast enhancement ratio (CER) was calculated. Time-to-CER curves were compared among the three groups. The differences in maximum CER (CERmax) and time-to-peak of CER were analyzed.

Results

The time-to-CER curve showed a double peak pattern in group A and single-peak pattern in groups B and C. The mean time between the first and the second peak was 6.2 s. The mean CERmax of each group was 4.50, 4.52 and 4.27, respectively. In group A, B and C, the mean time-to-peak was 14.6, 10.6 and 12.6 s, respectively. There was a significant difference between group A and B (P < 0.01).

Conclusion

To set up the optimal protocol for abdominal DCE-MRI, it should be noted that TIC in the Gd-DTPA and Gd-EOB-DTPA group showed different patterns, and a slower injection rate showed a less abrupt SI change in the Gd-EOB-DTPA group than in the Gd-DTPA group.

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Acknowledgments

We thank Kastuya Maruyama, Siemens Japan K.K., for comments on the MR sequences. This study was supported in part by the Ministry of Health, Labour and Welfare, research on hepatitis, and Japanese Health and Labor Sciences research grants for the development of early detection systems for liver cancer using molecular markers and diagnostic imagings.

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Authors and Affiliations

  1. Department of Radiology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Yasunari Fujinaga, Yoshinori Tsukahara, Yukiko Sugiyama & Masumi Kadoya

  2. Radiology Division of Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, 390-8621, Japan

    Hitoshi Ueda & Yoshihiro Kitou

Authors
  1. Yasunari Fujinaga
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  2. Hitoshi Ueda
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  3. Yoshihiro Kitou
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  4. Yoshinori Tsukahara
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  5. Yukiko Sugiyama
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  6. Masumi Kadoya
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Corresponding author

Correspondence to Yasunari Fujinaga.

Additional information

This study received the Certificate for the Best Poster at the 3rd Asian Congress of Abdominal Radiology (ACAR) meeting in Beijing (2011).

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Fujinaga, Y., Ueda, H., Kitou, Y. et al. Time-intensity curve in the abdominal aorta on dynamic contrast-enhanced MRI with high temporal and spatial resolution: Gd-EOB-DTPA versus Gd-DTPA in vivo. Jpn J Radiol 31, 166–171 (2013). https://doi.org/10.1007/s11604-012-0162-8

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  • DOI: https://doi.org/10.1007/s11604-012-0162-8

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