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CAR T Cell Therapy for Hematological Malignancies

Current Medical Science volume 39, pages874–882(2019)Cite this article

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Summary

As a rapidly progressing field in oncology, the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors (CARs) has shown striking efficacy in the management of hematological malignancies and has been reported in a number of clinical trials. Of note, CAR T cell therapy has shown extraordinary potential, especially in relapsed/refractory patients. However, there are still challenges regarding the further development of this strategy, spanning from engineering and manufacturing issues, to limited applications, to accompanying toxicities. In this review, we will summarize the general knowledge of this novel method, including receptor composition, applications, adverse events and challenges. Additionally, we will propose several comprehensive recommendations.

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Affiliations

  1. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xin Yang, Gao-xiang Wang & Jian-feng Zhou

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  1. Xin Yang
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  2. Gao-xiang Wang
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  3. Jian-feng Zhou
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Correspondence to Jian-feng Zhou.

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Conflict of Interest Statement

The authors have declared that they have no conflicts of interest.

This project was supported by the Key Program of the National Natural Science Foundation (NNSF) of China (No. 81230052 and No. 81630006).

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Yang, X., Wang, Gx. & Zhou, Jf. CAR T Cell Therapy for Hematological Malignancies. CURR MED SCI 39, 874–882 (2019). https://doi.org/10.1007/s11596-019-2118-z

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Key words

  • immune therapy
  • chimeric antigen receptor T cells
  • hematological malignancies