Summary
Marjolin’s ulcer (MU) is a rare but aggressive epidermoid carcinoma observed in scars or wounds. This article provides comprehensive characteristics and prognostic details of MU. Clinical data of 40 patients with MU between January 2010 and December 2017 were analyzed retrospectively. Squamous cell carcinoma was the most common pathological type (35/40, 87.5%). Extended resection was performed to treat all cases with skin grafting or flap grafting. Follow-up duration ranged from 6 to 96 months (median, 52 months) and recurrence was noted in 9 cases. The 1-, 3- and 5-year recurrence-free survival (RFS) rates were 87.2%, 87.2%, 83.2% respectively and the recurrence rate was 22.5%. Univariate analysis revealed that cause of scars (P=0.044), lesion appearance (P=0.036), ultraviolet radiation exposure (P=0.000), depth (P=0.001) and histological grade (P=0.027) had a statistically significant correlation with prognosis of MU. Multivariate analysis revealed that depth (P=0.034, RR=2.681, 95%CI: 1.077–6.674) and histological grade (P=0.008, RR=2.820, 95%CI: 1.315–6.050) were independent prognostic factors for RFS. In conclusion, superficial infiltration and high-grade differentiation predict more favorable prognosis. Careful follow-up of high-risk groups is strongly recommended to prevent recurrence and improve prognosis.
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References
Shahla A. An overview of heel Marjolin’s ulcers in the Orthopedic Department of Urmia University of Medical Sciences. Arch Iran Med, 2009,12(4):405–408
Shen R, Zhang J, Zhang F, et al. Clinical characteristics and therapeutic analysis of 51 patients with Marjolin's ulcers. Exp Ther Med, 2015,10(4):364–1374
Copcu E. Marjolin’s ulcer: a preventable complication of burns? Plast Reconstr Surg, 2009,124(1):156e-164e
Huang CY, Feng CH, Hsiao YC, et al. Burn scar carcinoma. J Dermatolog Treat, 2010,21(6):350–356
Kowal-Vern A, Criswell BK. Burn scar neoplasms: a literature review and statistical analysis. Burns, 2005,31(4): 403–413
Saaiq M, Ashraf B. Marjolin’s ulcers in the post-burned lesions and scars. World J Clin Cases, 2014,2(10):507–514
Qiu XJ, Zhang J, Wang J, et al. Application of paclitaxel as adjuvant treatment for benign cicatricial airway stenosis. J Huazhong Univ Sci Technolog Med Sci, 2016,36(6):817–822
Choi JY, Bae YC, Nam SB, et al. Impact of disturbed wound healing after surgery on the prognosis of Marjolin’s ulcer. Arch Plast Surg, 2013,40(3):198–202
Chalya PL, Mabula JB, Rambau P, et al. Marjolin’s ulcers at a university teaching hospital in Northwestern Tanzania: a retrospective review of 56 cases. World J Surg Oncol, 2012,10:38
Eroglu A, Camlibel S. Risk factors for locoregional recurrence of scar carcinoma. Br J Surg, 1997,84(12):1744–1746
Wallingford SC, CM Olsen, E Plasmeijer, et al. Skin cancer arising in scars: a systematic review. Dermatol Surg, 2011,37(9):1239–1244
Sadegh Fazeli M, Lebaschi AH, Hajirostam M, et al. Marjolin’s ulcer: clinical and pathologic features of 83 cases and review of literature. Med J Islam Repub Iran, 2013,27(4): 215–224
Challa VR, Deshmane V, Ashwatha Reddy MB. A Retrospective Study of Marjolin’s Ulcer Over an Eleven Year Period. J Cutan Aesthet Surg, 2014,7(3):155–159
Ye Z, Xie W, Long Z, et al. Analysis of diagnosis and management of 21 patients with Marjolin’s ulcers. Zhonghua Shao Shang Za Zhi (Chinese), 2014,30(6):491–494
Liu Z, Zhou Y, Zhang P, et al. Analysis of clinical characteristics of 187 patients with Marjolin’s ulcers. Zhonghua Shao Shang Za Zhi (Chinese), 2016,32(5): 293–298
Metwally IH, Roshdy A, Saleh SS, et al. Epidemiology and predictors of recurrence of Marjolin’s ulcer: experience from Mansoura Universityxs. Ann R Coll Surg Engl, 2016,99(3):245–249
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Guo, Bw., Pan, T., Chen, Hb. et al. Clinicopathologic Characteristics and Prognosis Analysis of Marjolin’s Ulcer in 40 Cases. CURR MED SCI 38, 1038–1044 (2018). https://doi.org/10.1007/s11596-018-1981-3
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DOI: https://doi.org/10.1007/s11596-018-1981-3