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CXCL12 G801A polymorphism and cancer risk: An updated meta-analysis

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Summary

Many studies have reported the relationship between CXCL12 G801A polymorphism and cancer risk, with conflicting results. In this study, we tried to clarify the possibility that this polymorphism may increase cancer risk by conducting an updated meta-analysis. PubMed and EMbase were searched for case-control studies regarding the association of the gene polymorphism and cancer risk. Data were extracted and odds ratios (ORs) with 95% confidence intervals (95% CIs) were used to assess the strength of the association. Heterogeneity among articles and publication bias was also assessed. Significantly increased risk for cancer was found (A vs. G: OR=1.26, 95% CI=1.13–1.40, P<0.01; AA+AG vs. GG: OR=1.33, 95% CI=1.16–1.52, P<0.01). In subgroup analysis, statistically elevated cancer risk was found in both Asian and Caucasian populations (for Asian, AA+AG vs. GG: OR=1.74, 95% CI=1.22–2.47, P<0.01; for Caucasian, AA+AG vs. GG: OR=1.24, 95% CI=1.09–1.42, P<0.01). Our result indicated that CXCL12 G801A polymorphism is a risk factor for cancer. To validate the finding, further large-size case-control studies are warranted.

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Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Dan Meng  (孟丹), Yin-xiang Wu  (邬引翔), Vidhi Heerah, Shuang Peng  (彭双), Meng-di Chu  (褚梦迪), Yong-jian Xu  (徐永健), Wei-ning Xiong  (熊维宁) & Shu-yun Xu  (许淑云)

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  1. Dan Meng  (孟丹)
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  2. Yin-xiang Wu  (邬引翔)
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Correspondence to Shu-yun Xu  (许淑云).

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This project was supported by grants from the National Natural Science Foundation of China (No. 81371939 and No. 81370134), Natural Science Foundation of Hubei Province, China (No. 2012FFB02422), and Wuhan Municipal Science and Technology Bureau, China (No. 2014060101010035).

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Meng, D., Wu, Yx., Heerah, V. et al. CXCL12 G801A polymorphism and cancer risk: An updated meta-analysis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 319–326 (2015). https://doi.org/10.1007/s11596-015-1431-4

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  • DOI: https://doi.org/10.1007/s11596-015-1431-4

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