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NGAL („neutrophil gelatinase-associated lipocalin“) – ein neuer Marker für das akute Nierenversagen

Neutrophil gelatinase-associated lipocalin – a new marker of acute kidney failure

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Literatur

  1. Kribben A, Herget-Rosenthal S, Pietruck F, Philipp T (2003) Acute renal failure – an review. Dtsch Med Wochenschr 128 (22):1231–1236

    Article  PubMed  CAS  Google Scholar 

  2. Venkataraman R, Kellum JA (2007) Prevention of acute renal failure. Chest 131(1):300–308

    Article  PubMed  CAS  Google Scholar 

  3. Mehta RL, Kellum JA, Shah SV et al (2007) Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31

    Article  PubMed  Google Scholar 

  4. Bjornsson TD (1979) Use of serum creatinine concentrations to determine renal function. Clin Pharmacokinet 4(3):200–222

    Article  PubMed  CAS  Google Scholar 

  5. Perrone RD, Madias NE, Levey AS (1992) Serum creatinine as an index of renal function: New insights into old concepts. Clin Chem 38(10):1933–1953

    PubMed  CAS  Google Scholar 

  6. Stevens L, Lafayette R, Perrone R et al (2007) Laboratory evaluation of kidney function. In: Diseases of the kidney and urinary tract. Lippincott, Williams and Wilkins, Philadelphia/PA

  7. Dagher PC, Herget-Rosenthal S, Ruehm SG et al (2003) Newly developed techniques to study and diagnose acute renal failure. J Am Soc Nephrol 14(8):2188–2198

    Article  PubMed  Google Scholar 

  8. Edelstein CL (2008) Biomarkers of acute kidney injury. Adv Chronic Kidney Dis 15(3):222–234

    Article  PubMed  Google Scholar 

  9. Coca SG, Yalavarthy R, Concato J, Parikh CR (2008) Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review. Kidney Int 73(9):1008–1016

    Article  PubMed  CAS  Google Scholar 

  10. Herget-Rosenthal S, Poppen D, Hüsing J et al (2004) Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis. Clin Chem 50(3):552–558

    Article  PubMed  CAS  Google Scholar 

  11. Liu Q, Nilsen-Hamilton M (1995) Identification of a new acute phase protein. J Biol Chem 270(38):22565–22570

    Article  PubMed  CAS  Google Scholar 

  12. Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268(14):10425–10432

    PubMed  CAS  Google Scholar 

  13. Devarajan P (2007) Neutrophil gelatinase-associated lipocalin: New paths for an old shuttle. Cancer Ther 5(B):463–470

    PubMed  Google Scholar 

  14. Devarajan P (2007) Emerging biomarkers of acute kidney injury. Contrib Nephrol 156:203–212

    Article  PubMed  Google Scholar 

  15. Xu S, Venge P (2000) Lipocalins as biochemical markers of disease. Biochim Biophys Acta 1482(1–2):298–307

    Google Scholar 

  16. Mori K, Lee HT, Rapoport D et al (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 115(3):610–621

    PubMed  CAS  Google Scholar 

  17. Mishra J, Dent C, Tarabishi R et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365(9466):1231–1238

    Article  PubMed  CAS  Google Scholar 

  18. Bennett M, Dent CL, Ma Q et al (2008) Urine NGAL predicts severity of acute kidney injury after cardiac surgery: A prospective study. Clin J Am Soc Nephrol 3(3):665–673

    Article  PubMed  Google Scholar 

  19. Wagener G, Gubitosa G, Wang S et al (2008) Increased incidence of acute kidney injury with aprotinin use during cardiac surgery detected with urinary NGAL. Am J Nephrol 28(4):576–582

    Article  PubMed  CAS  Google Scholar 

  20. Bachorzewska-Gajewska H, Malyszko J, Sitniewska E et al (2006) Neutrophil-gelatinase-associated lipocalin and renal function after percutaneous coronary interventions. Am J Nephrol 26(3):287–292

    Article  PubMed  CAS  Google Scholar 

  21. Hirsch R, Dent C, Pfriem H et al (2007) NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol 22(12):2089–2095

    Article  PubMed  Google Scholar 

  22. Mishra J, Ma Q, Kelly C et al (2006) Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol 21(6):856–863

    Article  PubMed  Google Scholar 

  23. Parikh CR, Jani A, Mishra J et al (2006) Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation. Am J Transplant 6(7):1639–1645

    Article  PubMed  CAS  Google Scholar 

  24. Trachtman H, Christen E, Cnaan A et al (2006) Urinary neutrophil gelatinase-associated lipocalcin in D+HUS: A novel marker of renal injury. Pediatr Nephrol 21(7):989–994

    Article  PubMed  Google Scholar 

  25. Mori K, Nakao K (2007) Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage. Kidney Int 71(10):967–670

    Article  PubMed  CAS  Google Scholar 

  26. Nickolas TL, O’Rourke MJ, Yang J et al (2008) Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med 148(11):810–819

    PubMed  Google Scholar 

  27. Mitsnefes MM, Kathman TS, Mishra J et al (2007) Serum neutrophil gelatinase-associated lipocalin as a marker of renal function in children with chronic kidney disease. Pediatr Nephrol 22(1):101–108

    Article  PubMed  Google Scholar 

  28. Bolignano D, Lacquaniti A, Coppolino G et al (2008) Neutrophil gelatinase-associated lipocalin reflects the severity of renal impairment in subjects affected by chronic kidney disease. Kidney Blood Press Res 31(4):255–258

    Article  PubMed  CAS  Google Scholar 

  29. Bolignano D, Donato V, Coppolino G et al (2008) Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 52(3):595–605

    Article  PubMed  CAS  Google Scholar 

  30. Nielsen BS, Borregaard N, Bundgaard JR et al (1996) Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 38(3):414–420

    Article  PubMed  CAS  Google Scholar 

  31. Nielsen OH, Gionchetti P, Ainsworth M et al (1999) Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8 and tumor necrosis factor-alpha in ulcerative colitis. Am J Gastroenterol 94(10):2923–2928

    PubMed  CAS  Google Scholar 

  32. Hemdahl AL, Gabrielsen A, Zhu C et al (2006) Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb Vasc Biol 26(1):136–142

    Article  PubMed  CAS  Google Scholar 

  33. Folkesson M, Kazi M, Zhu C et al (2007) Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. Thromb Haemost 98(2):427–433

    PubMed  CAS  Google Scholar 

  34. Elneihoum AM, Falke P, Hedblad B et al (1997) Leukocyte activation in atherosclerosis: correlation with risk factors. Atherosclerosis 131(1):79–84

    Article  PubMed  CAS  Google Scholar 

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Bruck, H. NGAL („neutrophil gelatinase-associated lipocalin“) – ein neuer Marker für das akute Nierenversagen. Nephrologe 4, 152–153 (2009). https://doi.org/10.1007/s11560-009-0282-z

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