Abstract
Purpose
Our aim was to develop an interactive 3D direct volume rendering (DVR) visualization solution to interpret and analyze complex, serial multi-modality imaging datasets from positron emission tomography–computed tomography (PET–CT).
Methods
Our approach uses: (i) a serial transfer function (TF) optimization to automatically depict particular regions of interest (ROIs) over serial datasets with consistent anatomical structures; (ii) integration of a serial segmentation algorithm to interactively identify and track ROIs on PET; and (iii) parallel graphics processing unit (GPU) implementation for interactive visualization.
Results
Our DVR visualization more easily identifies changes in ROIs in serial scans in an automated fashion and parallel GPU computation which enables interactive visualization.
Conclusions
Our approach provides a rapid 3D visualization of relevant ROIs over multiple scans, and we suggest that it can be used as an adjunct to conventional 2D viewing software from scanner vendors.
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References
Pfister H, Lorensen B, Bajaj C, Kindlmann G, Schroeder W, Avila L, Martin K, Machiraju R (2007) The transfer function bake-off. IEEE Comput Graph Appl 21(3):16–22
Correa C, Ma K (2011) Visibility histograms and visibility-driven transfer functions. IEEE Trans Vis Comput Graph 17(2):192–204
Qin H, Ye B, He R (2015) The voxel visibility model: an efficient framework for transfer function design. Comput Med Imaging Graph 40:138–146
Ma B, Entezari A (2018) Volumetric feature-based classification and visibility analysis for transfer function design. IEEE Trans Vis Comput Graph 25(1):3253–3267
Jung Y, Kim J, Eberl S, Fulham M, Feng D (2013) Visibility-driven PET–CT visualisation with region of interest (ROI) segmentation. Visual Comput 29(6–8):805–815
Tzeng F, Ma K (2005) Intelligent feature extraction and tracking for visualizing large-scale 4D flow simulations. In: Proceedings of ACM/IEEE supercomputing 05
Akiba H, Fout N, Ma K (2006) Simultaneous classification of time-vying volume data based on the time histogram. In: Proceedings of EuroVis 06
Maciejewski R, Woo I, Chen W, Ebert D (2009) Structuring feature space: a non-parametric method for volumetric transfer function generation. IEEE Trans Vis Comput Graph 15(6):1473–1480
Kim J, Hu Y, Eberl S, Feng D, Fulham M (2008) A fully automatic bed/linen segmentation for fused PET/CT MIP rendering. In: Proceedings of EMBC 08
Klein S, Staring M, Murphy K, Viergever MA, Pluim J (2010) Elastix: a toolbox for intensity-based medical image registration. IEEE Trans Med Imaging 29(1):196–205
Bi L, Kim J, Wen L, Kumar A, Fulham M, Feng D (2013) Cellular automata and anisotropic diffusion filter based interactive tumor segmentation for positron emission tomography. In: Proceedings of EMBC 13
Desbordes P, Petitjean C, Ruan S (2016) Segmentation of lymphoma tumor in PET images using cellular automata: a preliminary study. IRBM 37(1):3–10
Wahl R, Jacene H, Kasamon Y, Lodge MA (2009) From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med 50:122–150
Hamamci A, Kucuk N, Karaman K, Engin K, Unal G (2012) Tumor-cut: segmentation of brain tumors on contrast enhanced MR images for radiosurgery applications. IEEE Trans Med Imaging 31(3):790–804
Liu Y, Cheng H, Huang J, Zhang Y, Tang X (2012) An effective approach of lesion segmentation within the breast ultrasound image based on the cellular automata principle. J Digit Imaging 25(5):580–590
Lagarias J, Reeds J, Wright M, Wright P (1998) Convergence properties of the Nelder–Mead simplex method in low dimensions. SIAM J Optim 9(1):112–147
Kniss J, Kindlmann G, Hansen C (2001) Interactive volume rendering using multi-dimensional transfer functions and direct manipulation widgets. In: Proceedings of IEEE Vis 01
Meyer-Spradow J, Ropinski T, Mensmann J, Hinrichs K (2009) Voreen: a rapid-prototyping environment for ray-casting-based volume visualizations. IEEE Comput Graph Appl 29(6):6–13
Acknowledgements
This study was funded in part by the Australia Research Council (DP160103675).
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The authors declare that they have no conflict of interest.
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For this type of study, formal consent is not required. The testing data were collected at our institution with approval from the institutional review board.
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Informed consent was obtained from all individual participants included in the study.
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Jung, Y., Kim, J., Bi, L. et al. A direct volume rendering visualization approach for serial PET–CT scans that preserves anatomical consistency. Int J CARS 14, 733–744 (2019). https://doi.org/10.1007/s11548-019-01916-2
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DOI: https://doi.org/10.1007/s11548-019-01916-2