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Adenomyosis: from the sign to the diagnosis. Imaging, diagnostic pitfalls and differential diagnosis: a pictorial review

Adenomiosi: dal segno alla diagnosi. Imaging, errori diagnostici e diagnostica differenziale: pictorial review

  • Urogenital Radiology / Radiologia Uro-Genitale
  • Published:
La radiologia medica Aims and scope Submit manuscript

An Erratum to this article was published on 04 November 2011

An Erratum to this article was published on 04 November 2011

Abstract

Adenomyosis is a pathological gynaecological condition characterised by benign invasion of the endometrium into the myometrium. It is often misdiagnosed, or is not easily recognised, although it is responsible for disabling symptoms such as menorrhagia, abnormal uterine bleeding, dysmenorrhoea and infertility in premenopausal women. The aim of this pictorial review is to analyse the features of adenomyosis by illustrating the most usual and typical imaging patterns, along with the unusual appearances, seen in a vast array of gynaecological imaging modalities. The different findings of focal and diffuse adenomyosis along with the diagnostic limitations of ultrasound, hysterosalpingography and magnetic resonance imaging are described, as are the pitfalls and differential diagnosis with other pathological conditions that are often misdiagnosed as adenomyosis. The role of the different imaging modalities in planning appropriate treatment and their usefulness in monitoring therapy are also discussed.

Riassunto

L’adenomiosi è caratterizzata dall’invasione benigna del miometrio da parte dell’endometrio ed è spesso sottostimata o diagnosticata con ritardo, nonostante sia invalidante in quanto possibile causa di menorragia, metrorragia, dismenorrea ed infertilità. Lo scopo del lavoro è quello di analizzare gli aspetti diagnostici dell’adenomiosi mostrando i quadri più semplici e quelli più rari e difficili da caratterizzare, raccolti in una ampia galleria che prende in esame tutte le più note tecniche di imaging ginecologico. La forma diffusa di adenomiosi e quelle focali saranno analizzate sulla base dei segni di semeiotica elementare. I limiti e possibilità delle varie tecniche di imaging, ecografia, isterosalpingografia e risonanza magnetica, saranno illustrate ponendo anche particolare attenzione alla diagnostica differenziale con le altre forme morbose più facilmente equivocabili. Sarà infine discusso il ruolo delle metodiche di imaging nella pianificazione del tipo di trattamento e nel monitoraggio dell’efficacia terapeutica.

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References/Bibliografia

  1. Bird CC, McElin TW, Manalo Estrella P (1972) The elusive adenomyosis of the uterus revisited. Am J Obstet Gynecol 112:583–593

    PubMed  CAS  Google Scholar 

  2. Bergeron C, Amant F, Ferency A (2006) A pathology and physiopathology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:511–521

    Article  PubMed  Google Scholar 

  3. Silverberg S, Kurman R (1992) Tumor-like lesions. In: Rosai J (ed) Tumor of the uterine corpus and gestational trophoblastic disease. Armed Forces Institute of Pathology, Washington DC, pp 210–212

    Google Scholar 

  4. Vercellini P, Viganò P, Somigliana E et al (2006) Adenomyosis: epidemiological factors. Best Pract Res Clin Obstet Gynaecol 20:465–477

    Article  PubMed  Google Scholar 

  5. Utsunomiya D, Notsute S, Hayashida Y et al (2004) Endometrial carcinoma in adenomyosis: assessment of myometrial invasion on T2-weighted spin-echo and gadolinium-enhanced T1-weighted images. AJR Am J Roentgenol 182:399–404

    PubMed  Google Scholar 

  6. Peric H, Fraser IS (2006) The symptomatology of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:547–555

    Article  PubMed  CAS  Google Scholar 

  7. Pensa A, Favaro G (1970) Trattato di anatomia umana sistematica. Utet, Torino

    Google Scholar 

  8. Tamai K, Togashy K, Ito T et al (2005) MR imaging findings of adenomyosis: correlation with histopathologic features and diagnostic pitfalls. Radiographics 25:21–40

    Article  PubMed  Google Scholar 

  9. Wéry O, Thille A, Gaspard U et al (2005) Adenomyosis: update on a frequent but difficult diagnosis. J Gynecol Obstet Biol Reprod 34:633–648

    Google Scholar 

  10. Baker PM, Clement PB, Bell DA, Young RH (1999) Superficial endometriosis of the uterine cervix: a report of 20 cases of a process that may be confused with endocervical glandular dysplasia or adenocarcinoma in situ. Int J Gynecol Pathol 18:198–205

    Article  PubMed  CAS  Google Scholar 

  11. Dueholm M (2006) Transvaginal ultrasound for diagnosis of adenomyosis: a review. Best Pract Res Clin Obstet Gynaecol 20:569–682

    Article  PubMed  Google Scholar 

  12. Reinhold C, Tafazoli F, Mehio A et al (1999) Uterine adenomyosis: endovaginal US and MR imaging features with histopathologic correlation. Radiographics 19:S147–S160

    PubMed  Google Scholar 

  13. Simpson WL, Beitia L, Mester J (2006) Hysterosalpingography: a re-emerging study. Radiographics 26:419–443

    Article  PubMed  Google Scholar 

  14. De Souza NM, Hawley IC, Schwieso JE et al (1994) The uterine cervix on in vitro and in vivo MR images: a study of zonal anatomy and vascularity using an enveloping cervical coil. AJR Am J Roentgenol 163:607–612

    Google Scholar 

  15. Faquhar C, Brosens I (2006) Medical and surgical management of adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:603–616

    Article  Google Scholar 

  16. Fedele L, Bianchi E, Raffaelli R et al (1997) Treatment of adenomyosis associated menorrhagia with levonorgestrel-releasing intrauterine device. Fertil Steril 68:426–429

    Article  PubMed  CAS  Google Scholar 

  17. Igarashi M, Abe Y, Fukuda M et al (2000) Novel conservative medical therapy for uterine adenomyosis with danazol-loaded intrauterine device. Fertil Steril 74:412–413

    Article  PubMed  CAS  Google Scholar 

  18. Furuhashy M, Miyabe M, Katsumata Y et al (1998) Comparison of complication of vaginal hysterectomy in patients with leiomyomas and in patients with adenomyosis. Arch Gynecol Obstet 262:69–73

    Article  Google Scholar 

  19. Verma SK, Gonsalves CF, Baltarowich OH et al (2010) Spectrum of imaging findings on MRI and CT after uterine artery embolization. Abdom Imaging 35:118–128

    Article  PubMed  Google Scholar 

  20. Pelage JP, Jacob D, Fazel A et al (2005) Midterm results of uterine artery embolization for symptomatic adenomyosis: initial experience. Radiology 234:948–953

    Article  PubMed  Google Scholar 

  21. Siskin GP, Tublin ME, Stainken BF et al (2001) Uterine artery embolization for the treatment of adenomyosis clinical response and evaluation with MRI imaging. AJR Am J Roentgenol 177:297–302

    PubMed  CAS  Google Scholar 

  22. Sanghi NT, Hawes RH (1994) High-intensity focused ultrasound. Gastrointest Endosc Clin N Am 4:383–395

    Google Scholar 

  23. Rabinovici J, Stewart EA (2006) New interventional techniques for adenomyosis. Best Pract Res Clin Obstet Gynaecol 20:617–636

    Article  PubMed  Google Scholar 

  24. Hyninen K, Freund WR, Cline HE et al (1996) A clinical non-invasive MR imaging-monitored ultrasound surgery method. Radiographics 16:185–195

    Google Scholar 

  25. Kinkel K, Frei KA, Balleyguier C, Chapron C (2006) Diagnosis of endometriosis with imaging: a review. Eur Radiol 16:285–298

    Article  PubMed  Google Scholar 

  26. Katayama M, Masui T, Kpbayashy S et al (2001) Evaluation of pelvic adhesions using multiphase and multislide MR imaging with kinematic display. AJR Am J Roentgenol 177:107–110

    PubMed  CAS  Google Scholar 

  27. Manfredi R, Mirk P, Maresca G et al (2004) Local-regional staging of endometrial carcinoma: role of MR imaging in surgical planning. Radiology 231:372–378

    Article  PubMed  Google Scholar 

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Correspondence to A. L. Valentini.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s11547-011-0726-1

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Valentini, A.L., Speca, S., Gui, B. et al. Adenomyosis: from the sign to the diagnosis. Imaging, diagnostic pitfalls and differential diagnosis: a pictorial review. Radiol med 116, 1267–1287 (2011). https://doi.org/10.1007/s11547-011-0714-5

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  • DOI: https://doi.org/10.1007/s11547-011-0714-5

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