Modeling the Effect of Mucin Binding in the Gut on Drug Delivery
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An important part the absorption, distribution, metabolism and excretion of an oral therapeutic is the flux rate of drug compound crossing the mucus lining of the gut. To understand this part of the absorption process, we develop a mathematical model of advection, diffusion and binding of drug compounds within the mucus layer of the intestines. Analysis of this model yields simple, measurable criteria for the successful mucin layer traversal of drug compound.
KeywordsProtein binding ADME Intestinal mucus layer Mathematical model
Mathematics Subject Classification62P10 35Q99 65M99
We are pleased to acknowledge the support of AstraZeneca Discovery Sciences in Cambridge, UK and Shanghai, China, in exploring these relevant transport processes. We thank all the referees for their helpful and useful comments.
- Coddington A, Levinson N (1955) Theory of ordinary differential equations. International series in pure and applied mathematics. McGraw-Hill. https://books.google.com/books?id=LvNQAAAAMAAJ
- John F (1978) Parital differential equations. Applied mathematical sciences, vol 1, 3rd edn. Springer, BerlinGoogle Scholar
- Kearney P, Marriott C (1987) The effects of mucus glycoproteins on the bioavailability of tetracycline. iii. Everted gut studies. Int J Pharm 38(1–3):211–220Google Scholar
- Michaelis L, Menten ML (1913) Die kinetik der invertinwirkung. Biochem Z 49:333–369Google Scholar
- Williams FA (1985) Combustion theory (combustion science and engineering series). Addison-Wesley, ReadingGoogle Scholar
- Wolfram Research Inc.: Mathematica, Version 11.1. Champaign, IL (2017)Google Scholar