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Targeted Oncology

, Volume 13, Issue 2, pp 253–256 | Cite as

Retreatment with Vismodegib after Progression in Advanced Basal Cell Carcinoma: First-Time Report of a Single-Institution Experience

  • Salvatore Alfieri
  • Cristiana Bergamini
  • Roberta Granata
  • Laura Locati
  • Lisa Licitra
  • Paolo Bossi
Therapy in Practice

Abstract

Retreatment with vismodegib in advanced basal cell carcinoma (BCC) patients who previously discontinued the drug due to disease progression (PD) has not been reported yet. The objective of our report is to determine whether vismodegib is still active when used in BCC patients who progressed during a first vismodegib course (FVC). We conducted a retrospective study on six advanced BCC patients enrolled in a clinical trial (STEVIE, NCT01367665) who discontinued vismodegib due to PD and were then retreated with the same drug. All patients underwent intercurrent therapies between the FVC and the second vismodegib course (SVC). Disease control (complete response, CR; partial response, PR; and stable disease) was achieved in 100% and 80% of cases in FVC and SVC, respectively. The overall response rate was 80% for FVC (50% of CR) and 50% for SVC (only PR). Median treatment duration of FVC and SVC was 19.5 months (range: 13–35) and 8 months (range: 3–14+), respectively. G3-G4 AEs were reported only during SVC (two cases), leading to permanent discontinuation in one case. The median interval between FVC and SVC was 21.5 months (range: 13–30). After a median follow-up of 54 months (range: 46–63) only one patient with metastatic disease had rapid progression, discontinued vismodegib, and died. All other patients are still alive and two are currently on therapy. We concluded that vismodegib rechallenge is feasible and potentially active in advanced BCC patients who previously discontinued the drug due to disease progression.

Notes

Acknowledgments

Editorial assistance for the preparation of this manuscript was provided by Luca Giacomelli, PhD and Ambra Corti; this assistance was supported by internal funds.

Compliance with Ethical Standards

Funding

No funding was received for the preparation of this manuscript.

Conflict of Interest

Paolo Bossi has received consulting fee from Roche. Lisa Licitra has received consulting fees from Eisai, BMS, MSD, Merck-Serono, BI, Novartis, AstraZeneca, Bayer, and Roche; research funding from Eisai, MSD, Merck-Serono, BI, Novartis, AstraZeneca, and Roche; and other financial support from Merck-Serono and Bayer.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Department of Medical Oncology 3Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly
  2. 2.Department of Medical Oncology 3University of MilanMilanItaly

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