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Targeting FGFR in Squamous Cell Carcinoma of the Lung

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Abstract

Unlike for adenocarcinomas of the lung, no molecular targeted therapies have yet been developed for squamous cell lung cancers, because targetable oncogenic aberrations are scarce in this tumor type. Recent discoveries have established that the fibroblast growth factor (FGF) signaling pathway plays a fundamental role in cancer development by supporting tumor angiogenesis and cancer cell proliferation via different mechanisms. Through comprehensive genomic studies, aberrations in the FGF pathway have been identified in various tumor types, including squamous cell lung cancer, making FGF receptor (FGFR) a potentially druggable target in this malignancy. Several multi-targeted tyrosine kinase inhibitors include FGFR in their target spectrum and a number of these compounds have been approved for clinical use in different cancers. Novel agents selectively targeting FGFRs have been developed and are currently under investigation in clinical trials, showing promising results. This article reviews FGFR aberrations and the clinical data involving selective and multikinase FGFR inhibitors in squamous cell lung cancer.

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  1. Department of Medicine, Indiana University School of Medicine, 535 Barnhill Drive, RT 400, Indianapolis, IN, 46202, USA

    Neda Hashemi-Sadraei & Nasser Hanna

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  1. Neda Hashemi-Sadraei
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  2. Nasser Hanna
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Correspondence to Neda Hashemi-Sadraei.

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Dr. Hanna has received research funding from Merck and Bristol-Myers Squibb in the last 12 months. Dr. Hashemi-Sadraei declares no conflict of interest.

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Hashemi-Sadraei, N., Hanna, N. Targeting FGFR in Squamous Cell Carcinoma of the Lung. Targ Oncol 12, 741–755 (2017). https://doi.org/10.1007/s11523-017-0513-6

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