A three-compartment non-linear model of myocardial cell conduction block during photosensitization


This study constructed a new non-linear model of myocardial electrical conduction block during photosensitization reaction to identify the vulnerable cell population and generate an index for recurrent risk following catheter ablation for tachyarrhythmia. A three-compartment model of conductive, vulnerable, and blocked cells was proposed. To determine the non-linearity of the rate parameter for the change from vulnerable cells to conductive cells, we compared a previously reported non-linear model and our newly proposed model with non-linear rate parameters in the modeling of myocardial cell electrical conduction block during photosensitization reaction. The rate parameters were optimized via a bi-nested structure using measured synchronicity data during the photosensitization reaction of myocardial cell wires. The newly proposed model had a better fit to the measured data than the conventional model. The sum of the error until the time where the measured value was higher than 0.6, was 0.22 in the conventional model and 0.07 in our new model. The non-linear rate parameter from the vulnerable cell to the conductive cell compartment may be the preferred structure of the electrical conduction block model induced by photosensitization reaction. This simulation model provides an index to evaluate recurrent risk after tachyarrhythmia catheter ablation by photosensitization reaction.

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A three-compartment non-linear model of myocardial cell conduction block during photosensitization

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We thank J. Ludovic Croxford, PhD, from Edanz Group (https://en-author-services.edanz.com/ac) for editing a draft of this manuscript.

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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Emiyu Ogawa, Eitaro Aiyoshi, and Tsunenori Arai. The first draft of the manuscript was written by Emiyu Ogawa, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.


This work was supported in part by the Japan Agency for Medical Research and Development.

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Correspondence to Emiyu Ogawa.

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This study had no human participants.

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A research grant from the Japan Agency for Medical Research and Development was awarded to Tsunenori Arai (16im0210204h0002).

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Ogawa, E., Aiyoshi, E. & Arai, T. A three-compartment non-linear model of myocardial cell conduction block during photosensitization. Med Biol Eng Comput 59, 703–710 (2021). https://doi.org/10.1007/s11517-021-02329-7

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  • Photodynamic therapy (PDT)
  • NPe6
  • Laserphyrin
  • Cardiomyocyte
  • Bi-nested structure