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Monitoring respiratory rates with a wearable system using a stretchable strain sensor during moderate exercise

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Abstract

Respiratory rate, a sensitive indicator of respiratory status, is rarely measured during the field walking test. Our objective was to develop and validate a non-invasive, wearable monitoring system using stretchable strain sensors and an accompanying algorithm capable of providing real-time measurements of respiration during exercise. Twenty-four healthy volunteers wore stretchable sensors during a walking test protocol that included standing, sitting, walking, and walking with a stick. Sensors were placed on the ribcage and abdomen. The Bland-Altman method was used to assess the accuracy and precision of breath counts; total respiration time and inspiration time ratio were determined by custom algorithms and compared with measurements obtained with the standard flow sensor. The output signal from the stretchable sensor was highly synchronized with flow signals. The limits of agreement were within 3 breaths/min throughout the test protocol. Differences between sensors for total respiration time and inspiration time ratio were less than 14% and 26%, respectively. The agreement was maintained regardless of respiratory rate or volume. The wearable respiratory monitoring system yielded accurate and precise breath counts and total duration of respiratory cycle during moderate exercise in healthy young individuals, suggesting that it might be useful in clinical practice.

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Abbreviations

ABD:

Abdomen

BC:

Breath count

FLOW:

Flow sensor

LOA:

Limit of agreement

RC:

Ribcage

RMSRD:

Root mean square relative difference

STR:

Stretchable strain sensor

STS:

Sit-to-stand/stand-to-sit

TT:

Total time of respiratory duration

TITT:

Time of inspiration per total time of respiratory duration (inspiration time ratio)

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Funding

The study was funded by a grant from Bando Chemical Industries Ltd, and was partly supported by a grant from JSPS KAKENHI Grant Numbers JP17K17502, Grant-in-Aid for Young Scientists (B), and JP18K10744.

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Authors and Affiliations

  1. Department of Community Health Sciences, Graduate School of Health Sciences, Kobe University, 7-10-2 Tomogaoka, Suma-ku, Kobe-si, Hyogo, 654-0142, Japan

    Akio Yamamoto, Yutaro Oki, Kumiko Ono, Yukari Fujimoto & Akira Ishikawa

  2. Department of System Science, Graduate School of System Informatics, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan

    Hiroyuki Nakamoto

  3. New Business Promotion Center, Bando Chemical Industries, Ltd., 4-6-6 Minatojimaminamimachi, Chuou-ku, Kobe-si, Hyogo, 650-0047, Japan

    Yusuke Bessho

  4. Eikokai Ono Hospital, 973, Tenjin-cho, Ono-si, Hyyogo, 675-1316, Japan

    Yu Watanabe

  5. Department of Engineering, Graduate School of Engineering, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan

    Tsutomu Terada

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  1. Akio Yamamoto
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Contributions

The literature search was done by AY, YO, YG and YW; data collection by AY, YB, YO, YF, YW, and KO; and all authors contributed to study design. Data analysis was done by AY, manuscript preparation by AY, and manuscript review was done by all the authors.

Corresponding author

Correspondence to Akio Yamamoto.

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Conflict of interest

AY, HN, TT, AI received research grants and part of the experimental materials used for data collection from Bando Chemical Industries Ltd. YB is an employee of Bando Chemical Industries, Ltd.

Ethical approval

All procedures were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments. The study was approved by the ethical standards of the Committee on Human Experimentation at the Graduate School of Health Sciences, Kobe University.

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Individual written informed consent was obtained from all participants included in the study.

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Yamamoto, A., Nakamoto, H., Bessho, Y. et al. Monitoring respiratory rates with a wearable system using a stretchable strain sensor during moderate exercise. Med Biol Eng Comput 57, 2741–2756 (2019). https://doi.org/10.1007/s11517-019-02062-2

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  • DOI: https://doi.org/10.1007/s11517-019-02062-2

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