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An epigenetic perspective on the failing heart and pluripotent-derived-cardiomyocytes for cell replacement therapy

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Frontiers in Biology

Abstract

As life expectancy rises, the prevalence of heart failure is steadily increasing, while donors for organ transplantation remain in short supply (Zwi-Dantsis and Gepstein, 2012). Indeed, myocardial infarction represents the foremost cause of death within industrialized nations (Henning, 2011) and further, approximately 1% of all newborns harbor a congenital heart defect. Although medical interventions allow > 80% of those with cardiac defects to survive to adulthood, there are often extreme emotional and financial burdens that accompany such congenital anomalies, and many individuals will remain at a heightened risk for myocardial infarction throughout the remainder of their lives (Verheugt et al., 2010; Amianto et al., 2011). In this review, we will discuss the nature of the failing heart and strategies for repair from an epigenetic standpoint. Significant focus will reside on pluripotent-to-cardiomyocyte differentiation for cell replacement, epigenetic mechanisms of cardiomyocyte differentiation, epigenetic “memories,” and epigenetic control of cardiomyocyte cell fate toward translational utility.

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Authors and Affiliations

  1. Department of Diabetes and Metabolic Disease Research, Beckman Research Institute/City of Hope National Medical Center, 1500 E Duarte Road, Duarte, CA, 91010, USA

    Joshua D. Tompkins & Arthur D. Riggs

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  1. Joshua D. Tompkins
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  2. Arthur D. Riggs
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Correspondence to Joshua D. Tompkins.

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Tompkins, J.D., Riggs, A.D. An epigenetic perspective on the failing heart and pluripotent-derived-cardiomyocytes for cell replacement therapy. Front. Biol. 10, 11–27 (2015). https://doi.org/10.1007/s11515-014-1340-0

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  • DOI: https://doi.org/10.1007/s11515-014-1340-0

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