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Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering (SERS) and basic applications of SERS biological sensing

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Abstract

We review recent our results in the fundamental study of surface-enhanced Raman scattering (SERS) with emphasis on experiments that attempted to identify the enhancement and blinking mechanism using single Ag nanoparticle dimers attached to dye molecules. These results are quantitatively discussed in the framework of electromagnetic mechanism. We also review recent our results in basic SERS applications for biological sensing regarding detections of cell surface molecules and distinction of disease marker molecules under single cell and single molecule level.

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Authors and Affiliations

  1. Nano-Bioanalysis Research Group, Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, 761-0395, Japan

    Yuko S. Yamamoto & Tamitake Itoh

  2. Department of Chemistry, Josai University, Itado, Saitama, 350-0295, Japan

    Mitsuru Ishikawa

  3. Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda, Hyogo, 669-1337, Japan

    Yukihiro Ozaki

Authors
  1. Yuko S. Yamamoto
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  2. Mitsuru Ishikawa
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  3. Yukihiro Ozaki
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  4. Tamitake Itoh
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Correspondence to Tamitake Itoh.

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Yamamoto, Y.S., Ishikawa, M., Ozaki, Y. et al. Fundamental studies on enhancement and blinking mechanism of surface-enhanced Raman scattering (SERS) and basic applications of SERS biological sensing. Front. Phys. 9, 31–46 (2014). https://doi.org/10.1007/s11467-013-0347-3

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  • DOI: https://doi.org/10.1007/s11467-013-0347-3

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