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Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies

口服结肠靶向的纳米递送系统:原理及设计策略

  • Progress
  • Chemistry
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Science Bulletin

Abstract

Colon-targeted oral delivery is crucial for the treatment of colon-related diseases, as this delivery strategy enables precise drug administration to the diseased site, enhances drug bioavailability, and improves patient compliance. In particular, nanoparticle-based oral formulations shield drugs from the harsh gastrointestinal environment, and selectively increase drug concentration inside diseased colon cells, thus elevating therapeutic efficacy while reducing systemic toxicity. In this review, we elaborate recent progress in this area, with emphasis on the pathophysiological characteristics of colon site and design strategies to take advantage of these characteristics for colon targeting.

摘要

设计口服结肠靶向的递送系统对于治疗结肠有关的疾病非常重要,因为这种方式能够使药物精确施用到病变部位,提高药物生物利用度和患者的顺应性。尤其,以纳米粒子为基础的口服制剂可以保护药物在恶劣的胃肠道环境中不被破坏,并选择性地增加病变结肠部位的药物浓度,从而提高治疗功效、降低全身毒性。本文阐述了这方面的最新进展,重点总结了结肠部位的病生理特征和以此为依据的靶向设计策略。

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81471779), the National Thousand Young Talents Program, and the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning.

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The authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Department of Pharmacology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

      Lei Lu, Gaoxian Chen, Yuanyuan Qiu, Mingwang Li, Dianhua Liu, Dehui Hu, Xiajing Gu & Zeyu Xiao

    2. Translational Medicine Collaborative Innovation Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

      Lei Lu, Gaoxian Chen, Yuanyuan Qiu, Mingwang Li & Zeyu Xiao

    3. Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China

      Zeyu Xiao

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    1. Lei Lu
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    Correspondence to Zeyu Xiao.

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    Lei Lu and Gaoxian Chen contributed equally to this work.

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    Lu, L., Chen, G., Qiu, Y. et al. Nanoparticle-based oral delivery systems for colon targeting: principles and design strategies. Sci. Bull. 61, 670–681 (2016). https://doi.org/10.1007/s11434-016-1056-4

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