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A high strength, anti-fouling, self-healable, and thermoplastic supramolecular polymer hydrogel with low fibrotic response

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Abstract

The fibrotic response plays an important role in the performance and longevity of implantable devices. Thus, development of effective anti-inflammatory and anti-fibrosis biomaterial implants has become an urgent task. In this work, we developed a novel supramolecular polymer hydrogel through the copolymerization of N-acryloyl glycinamide (NAGA) and carboxybetaine acrylamide (CBAA) in the absence of any chemical crosslinker, which the mechanical properties being tunable through changing the monomer concentration and the monomer ratio over a broad scope. The hydrogel possessed the superior mechanical performances: high tensile strength (~1.13 MPa), large stretchability (~1200%), and excellent compressive strength (~9 MPa) at high monomer concentration and NAGA/CBAA ratio. Introduction of CBAA could promote the self-healability, thermoplasticity of suparmolecular polymer hydrogels at lower temperatures, meanwhile dramatically improving anti-fouling property. Histological analysis and in vitro cytotoxicity assays testified the excellent biocompatibility of the hydrogel. This high strength supramolecular polymer hydrogel with integrated multiple functions holds promising potentials as a scaffold biomaterial for treating degenerated soft supporting tissues.

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Correspondence to JianHai Yang or WenGuang Liu.

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Wang, H., Li, H., Wu, Y. et al. A high strength, anti-fouling, self-healable, and thermoplastic supramolecular polymer hydrogel with low fibrotic response. Sci. China Technol. Sci. 62, 569–577 (2019). https://doi.org/10.1007/s11431-018-9371-0

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  • DOI: https://doi.org/10.1007/s11431-018-9371-0

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