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Profile of Dr. Jia Fan

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Selected Publications (2014–2019)

  • Cai, J., Shi, G., Dong, Z., Ke, A., Ma, H., Gao, Q., Shen, Z., Huang, X., Chen, H., Yu, D., et al. (2015). Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression. Hepatology 61, 1603–1614.

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  • Dong, L.Q, Shi, Y., Ma, L.J., Yang, L.X., Wang, X.Y., Zhang, S., Wang, Z.C., Duan, M., Zhang, Z., Liu, L.Z., et al. (2018). Spatial and temporal clonal evolution of intrahepatic cholangiocarcinoma. J Hepatol 69, 89–98.

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  • Duan, M., Goswami, S., Shi, J., Wu, L., Wang, X., Ma, J., Zhang, Z., Shi, Y., Ma, L., Zhang, S., et al. (2019). Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma. Clin Cancer Res, 25, 3304–3316.

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  • Duan, M., Hao, J., Cui, S., Worthley, D.L., Zhang, S., Wang, Z., Shi, J., Liu, L., Wang, X., Ke, A., et al. (2018). Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing. Cell Res 28, 359–373.

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  • Duan, M., Wang, Z., Wang, X., Shi, J., Yang, L., Ding, Z., Gao, Q., Zhou, J., Fan, J. (2015). TREM-1, an inflammatory modulator, is expressed in hepatocellular carcinoma cells and significantly promotes tumor progression. Ann Surg Oncol 22, 3121–3129.

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  • Gao, Q., Wang, Z., Duan, M., Lin, Y., Zhou, X., Worthley, D., Wang, X., Niu, G., Xia, Y., Deng, M., et al. (2017). Cell culture system for analysis of genetic heterogeneity within hepatocellular carcinomas and response to pharmacologic agents. Gastroenterology 152, 232–242.e4.

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  • Gao, Q., Zhao, Y., Wang, X., Guo, W., Gao, S., Wei, L., Shi, J., Shi, G., Wang, Z., Zhang, Y., et al. (2014). Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients. Gastroenterology 146, 1397–1407.

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  • Guo, W., Sun, Y., Shen, M., Ma, X., Wu, J., Zhang, C., Zhou, Y., Xu, Y., Hu, B., Zhang, M., et al. (2018). Circulating tumor cells with stem-like phenotypes for diagnosis, prognosis, and therapeutic response evaluation in hepatocellular carcinoma. Clin Cancer Res 24, 2203–2213.

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  • Guo, W., Yang, X., Sun, Y., Shen, M., Ma, X., Wu, J., Zhang, C., Zhou, Y., Xu, Y., Hu, B., et al. (2014). Clinical significance of EpCAM mRNA-positive circulating tumor cells in hepatocellular carcinoma by an optimized negative enrichment and qRT-PCR-based platform. Clin Cancer Res 20, 4794–4805.

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  • Hu, B., Yang, X., Xu, Y., Sun, Y., Sun, C., Guo, W., Zhang, X., Wang, W., Qiu, S., Zhou, J., et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res 20, 6212–6222.

  • Jiang, Y., Sun, A., Zhao, Y., Ying, W., Sun, H., Yang, X., Xing, B., Sun, W., Ren, L., Hu, B., et al. (2019). Chinese human proteome project C: Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma. Nature 567, 257–261.

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  • Liu, L., Zhang, Z., Zheng, B., Shi, Y., Duan, M., Ma, L., Wang, Z., Dong, L., Dong, P., et al. (2019). CCL15 recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma. Hepatology 69, 143–159.

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  • Sun, Y., Guo, W., Xu, Y., Shi, Y., Gong, Z., Ji, Y., Du, M., Zhang, X., Hu, B., Huang, A., et al. (2018). Circulating tumor cells from different vascular sites exhibit spatial heterogeneity in epithelial and mesenchymal composition and distinct clinical significance in hepatocellular carcinoma. Clin Cancer Res 24, 547–559.

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  • Wang, Z., Gao, Q., Shi, J., Guo, W., Yang, L., Liu, X., Liu, L., Ma, L., Duan, M., Zhao, Y., et al. (2015). Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition. Hepatology 62, 1201–1214.

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  • Wang, Z., Peng, Y., Hu, J., Wang, X., Sun, H., Sun, J., Shi, Y., Xiao, Y., Ding, Z., Yang, X., et al. (2018). Associating liver partition and portal vein ligation for staged hepatectomy for unresectable hepatitis B virus- related hepatocellular carcinoma: A single center study of 45 patients. Ann Surg, doi: https://doi.org/10.1097/sla.0000000000002942

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  • Yang, L., Gao, Q., Shi, J., Wang, Z., Zhang, Y., Gao, P., Wang, X., Shi, Y., Ke, A., Shi, G., et al. (2015). Mitogen-activated protein kinase kinase kinase 4 deficiency in intrahepatic cholangiocarcinoma leads to invasive growth and epithelial-mesenchymal transition. Hepatology 62, 1804–1816.

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  • Ye, J., Li, T., Xu, G., Zhao, Y., Zhang, N., Fan, J., Wu, J. (2017). JCAD promotes progression of nonalcoholic steatohepatitis to liver cancer by inhibiting LATS2 kinase activity. Cancer Res 77, 5287–5300.

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  • Yue, X., Ai, J., Xu, Y., Chen, Y., Huang, M., Yang, X., Hu, B., Zhang, H., He, C., Yang, X., et al. (2017). Polymeric immunoglobulin receptor promotes tumor growth in hepatocellular carcinoma. Hepatology 65, 1948–1962.

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Profile of Dr. Jia Fan. Sci. China Life Sci. 62, 1136–1137 (2019). https://doi.org/10.1007/s11427-019-9574-1

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  • DOI: https://doi.org/10.1007/s11427-019-9574-1

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