Science China Life Sciences

, Volume 61, Issue 3, pp 355–357 | Cite as

Celastrol specifically inhibits the activation of NLRP3 inflammasome

Letter to the Editor


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.



This work was supported by the Natural Science Foundation of China (31570895, 31370892, 91429307), National Key Basic Research Programs (2015CB554302, 2014CB541905), and International Partnership Program of Chinese Academy of Sciences (153831KYSB20160009).

Supplementary material

11427_2017_9048_MOESM1_ESM.docx (33 kb)


  1. Chuang, S.Y., Lin, C.H., and Fang, J.Y. (2014). Natural compounds and aging: between autophagy and inflammasome. BioMed Res Int 2014, 1–10.CrossRefGoogle Scholar
  2. de Zoete, M.R., Palm, N.W., Zhu, S., and Flavell, R.A. (2014). Inflammasomes. Cold Spring Harbor Perspectives Biol 6, a016287–a016287.CrossRefGoogle Scholar
  3. Guo, H., Callaway, J.B., and Ting, J.P.Y. (2015). Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med 21, 677–687.CrossRefPubMedPubMedCentralGoogle Scholar
  4. Kannaiyan, R., Shanmugam, M.K., and Sethi, G. (2011). Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer. Cancer Lett 303, 9–20.CrossRefPubMedGoogle Scholar
  5. Salminen, A., Lehtonen, M., Paimela, T., and Kaarniranta, K. (2010). Celastrol: molecular targets of Thunder God Vine. Biochem Biophys Res Commun 394, 439–442.CrossRefPubMedGoogle Scholar
  6. Shao, B.Z., Xu, Z.Q., Han, B.Z., Su, D.F., and Liu, C. (2015). NLRP3 inflammasome and its inhibitors: a review. Front Pharmacol 6, 262.CrossRefPubMedPubMedCentralGoogle Scholar
  7. Shi, J., Gao, W., and Shao, F. (2017). Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci 42, 245–254.CrossRefPubMedGoogle Scholar
  8. Vanaja, S.K., Rathinam, V.A.K., and Fitzgerald, K.A. (2015). Mechanisms of inflammasome activation: recent advances and novel insights. Trends Cell Biol 25, 308–315.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Yu, X., Tao, W., Jiang, F., Li, C., Lin, J., and Liu, C. (2010). Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1. Am J Hyperten 23, 895–903.CrossRefGoogle Scholar

Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Xuesong Sang
    • 1
    • 2
  • Yihui Chen
    • 1
  • Wei Chen
    • 1
  • Jing Xie
    • 3
    • 4
  • Guangxun Meng
    • 1
  • Jin Zhong
    • 1
  • Taisheng Li
    • 3
    • 4
  • Ailing Lu
    • 1
  1. 1.CAS Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of ShanghaiChinese Academy of SciencesShanghaiChina
  2. 2.School of Life SciencesShanghai UniversityShanghaiChina
  3. 3.Department of Infectious Diseases, Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina
  4. 4.Clinical Immunology CenterChinese Academy of Medical SciencesBeijingChina

Personalised recommendations