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Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell

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Abstract

Dehydrogenative cyclization of thioamides is an attractive approach for the synthesis of S-heterocycles. Reported herein is an electrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis cell. The continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal- and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21672178) and Fundamental Research Funds for the Central Universities.

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Authors and Affiliations

  1. State Key Laboratory of Physical Chemistry of Solid Surfaces, Innovative Collaboration Center of Chemistry for Energy Materials, Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China

    Chong Huang & Hai-Chao Xu

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  1. Chong Huang
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  2. Hai-Chao Xu
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Correspondence to Hai-Chao Xu.

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Conflict of interest The authors declare that they have no conflict of interest.

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Huang, C., Xu, HC. Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell. Sci. China Chem. 62, 1501–1503 (2019). https://doi.org/10.1007/s11426-019-9554-1

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  • DOI: https://doi.org/10.1007/s11426-019-9554-1

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