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Applications of CBT-Cys click reaction: past, present, and future

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Abstract

Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole (CBT) and D-cysteine (D-Cys) in fireflies and has high biocompatibility and controllability in physiological solutions. Under the control of pH, reduction, or enzyme, this CBT-based click reaction has been widely applied to a wide range of biomedical fields such as protein labeling, molecular imaging (e. g., optical imaging, nuclear imaging, magnetic resonance imaging and photoacoustic imaging), nanomaterial fabrication, cancer therapy, and other potentialities.

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Acknowledgements

This work was supported by the Ministry of Science and Technology of China (2016YFA0400904), the National Natural Science Foundation of China (21725505, 21675145), and the Major program of Development Foundation of Hefei Center for Physical Science and Technology (2016FXZY006).

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  1. Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China

    Miaomiao Zhang & Gaolin Liang

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  1. Miaomiao Zhang
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  2. Gaolin Liang
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Correspondence to Gaolin Liang.

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Zhang, M., Liang, G. Applications of CBT-Cys click reaction: past, present, and future. Sci. China Chem. 61, 1088–1098 (2018). https://doi.org/10.1007/s11426-018-9277-6

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