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Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes

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Abstract

Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus (S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21727817, 21390414, 21425522, 51571185) and Beijing Science and Technology Commission Special Project for Frontier Technology in Life Sciences (Z171100000417008).

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  1. These authors contributed equally to this work.

Authors and Affiliations

  1. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, China

    Xiangchun Zhang, Li Liu, Ru Liu, Jing Wang, Xuhu Hu, Qing Yuan, Juanjuan Guo, Gengmei Xing, Yuliang Zhao & Xueyun Gao

  2. Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing, 100124, China

    Xueyun Gao

  3. University of Chinese Academy of Sciences, Beijing, 100049, China

    Xiangchun Zhang

Authors
  1. Xiangchun Zhang
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  2. Li Liu
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  3. Ru Liu
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  4. Jing Wang
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  5. Xuhu Hu
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  10. Xueyun Gao
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Corresponding authors

Correspondence to Ru Liu or Xueyun Gao.

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11426_2017_9206_MOESM1_ESM.pdf

Specific Detection and Effective Inhibition of a Single Bacterial Species in situ Using Peptide Mineralized Au Cluster Probes

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Zhang, X., Liu, L., Liu, R. et al. Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes. Sci. China Chem. 61, 627–634 (2018). https://doi.org/10.1007/s11426-017-9206-y

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  • DOI: https://doi.org/10.1007/s11426-017-9206-y

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