Specific detection and effective inhibition of a single bacterial species in situ using peptide mineralized Au cluster probes

  • Xiangchun Zhang
  • Li Liu
  • Ru Liu
  • Jing Wang
  • Xuhu Hu
  • Qing Yuan
  • Juanjuan Guo
  • Gengmei Xing
  • Yuliang Zhao
  • Xueyun Gao


Increasingly serious microbial infections call for the development of new simpler methods for the precise diagnosis and specific inhibition of such pathogens. In this work, a peptide mineralized Au cluster probe was applied as a new simplified strategy to both recognize and inhibit a single bacteria species of Staphylococcus aureus (S. aureus) simultaneously. The probes are composed of peptides and Au clusters. Moreover, the peptides specifically target S. aureus cells and the Au clusters provide fluorescent imaging and have an antibacterial effect. These new probes enable the simultaneous specific detection and effective destruction S. aureus cells in situ.


Au cluster probes single bacteria species S. aureus specific detection effective inhibition 


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This work was supported by the National Natural Science Foundation of China (21727817, 21390414, 21425522, 51571185) and Beijing Science and Technology Commission Special Project for Frontier Technology in Life Sciences (Z171100000417008).

Supplementary material

11426_2017_9206_MOESM1_ESM.pdf (1.3 mb)
Specific Detection and Effective Inhibition of a Single Bacterial Species in situ Using Peptide Mineralized Au Cluster Probes


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Xiangchun Zhang
    • 1
    • 3
  • Li Liu
    • 1
  • Ru Liu
    • 1
  • Jing Wang
    • 1
  • Xuhu Hu
    • 1
  • Qing Yuan
    • 1
  • Juanjuan Guo
    • 1
  • Gengmei Xing
    • 1
  • Yuliang Zhao
    • 1
  • Xueyun Gao
    • 1
    • 2
  1. 1.CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy PhysicsChinese Academy of SciencesBeijingChina
  2. 2.Department of Chemistry and Chemical EngineeringBeijing University of TechnologyBeijingChina
  3. 3.University of Chinese Academy of SciencesBeijingChina

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