Science China Chemistry

, Volume 61, Issue 5, pp 604–612 | Cite as

GMP-quadruplex-based hydrogels stabilized by lanthanide ions

  • Jin Zhang
  • Xiaoyang Li
  • Xiuping Sun
  • Aixin Song
  • Yebang Tan
  • Jingcheng Hao


This work describes the gelation behaviors and properties of a biological molecule, guanosine 5′-monophosphate disodium salt (GMP), in the presence of trivalent lanthanide ions. Hydrogels composed of GMP-quadruplexes were prepared by adjusting pH, through which the protonation of phosphate group was controlled to tune the interactions between lanthanide ions and GMP. Within the pH region of 2–6, the electrostatic interaction between lanthanide ions and phosphate group is hindered and the cation-dipole interaction acts as the main driving force for the formation of G-quadruplexes. All the hydrogels were found consisting of three-dimensional network of the intertwining one-dimensional nanofibers formed by the stacking G-quartets induced by lanthanide ions. A significant fluorescence enhancement of thioflavin T (ThT), a fluorescent molecule, was found to be triggered by the G-quadruplex structures, for which the rotation of chromophoric groups on ThT molecules were prohibited due to the implant into the G-quadruplex structures.


G-quadruplex hydrogel hydrogen bonding electrostatic interaction ion-dipole interaction fluorescence enhancement 


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This work was supported by the National Natural Science Foundation of China (21573134, 21420102006).


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Copyright information

© Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Jin Zhang
    • 1
  • Xiaoyang Li
    • 1
  • Xiuping Sun
    • 1
  • Aixin Song
    • 1
  • Yebang Tan
    • 1
  • Jingcheng Hao
    • 1
  1. 1.Key Laboratory of Colloid and Interface Chemistry, Ministry of EducationShandong UniversityJinanChina

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