Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on H2O2-damaged pancreatic cells

A Correction to this article was published on 13 August 2019

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Abstract

Four new cucurbitane-type triterpenes were isolated from the fruit of Momordica charantia L. The structures of the new compounds were identified based on HR-ESI-MS and 1D- and 2D-NMR spectroscopic methods. The cytotoxicity of the isolated compounds was evaluated using three human cancer cell lines, HeLa, Caco2, and U87. Compound 3 exhibited significant cytotoxic activity against HeLa cells with an IC50 value of 11.18 μM. Additionally, the cytoprotective activity of these compounds was determined in vitro against H2O2-induced pancreatic injury. The results revealed that all the compounds obtained possess cytoprotective effects against H2O2-induced injury in MIN6 β-cells at a concentration of 10 μM.

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  • 13 August 2019

    In the original publication of the article, affiliations of authors were published incorrectly. The correct information is provided below.

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Acknowledgements

We are glad to acknowledge the Analytical Center of Shenyang Pharmaceutical University for NMR measurements. The research was supported by National Nature Science Foundation of China (Grant No. 81703389), Youth development support plan of Shenyang Pharmaceutical University (ZQN2016023), Liaoning E & T research center for industrial chromatographic preparation of Natural Products (No. 2008402021), Technology Platform of Industrialization Chromatographic Preparation for Standard Extract of Traditional Chinese Medicine (2010ZX09401-304), and Liaoning (FGW) Engineering Technology Research Center for industrial chromatographic preparation of natural innovative drugs materials (2017-1007).

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Yue, J., Sun, Y., Xu, J. et al. Four new cucurbitane-type triterpenes from Momordica charantia L. with their cytotoxic activities and protective effects on H2O2-damaged pancreatic cells. J Nat Med 74, 34–40 (2020). https://doi.org/10.1007/s11418-019-01336-1

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Keywords

  • Momordica charantia L.
  • Cucurbitane-type triterpenoid sapogenins
  • Cytotoxic activity
  • Protection of pancreatic cell oxidative injury