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Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

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Abstract

A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism.

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Acknowledgements

This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University.

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Authors and Affiliations

  1. State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Molecular Drug Research, College of Pharmacy, Nankai University, Tianjin, 300350, People’s Republic of China

    Yuan Shuo, Chenyue Zhang, Xueyuan Yang, Feng Liu, Qi Zhang, Annan Li, Jun Ma & Yuanqiang Guo

  2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea

    Dongho Lee

  3. Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai, 989-3201, Japan

    Yasushi Ohizumi

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  1. Yuan Shuo
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  2. Chenyue Zhang
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  4. Feng Liu
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  5. Qi Zhang
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  6. Annan Li
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  7. Jun Ma
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  9. Yasushi Ohizumi
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  10. Yuanqiang Guo
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Correspondence to Yuanqiang Guo.

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11418_2019_1324_MOESM1_ESM.doc

Appendix A: Supplementary data. 1D and 2D NMR spectra of 1 are available as supplementary data. Supplementary data related to this article can be found online. 1 (DOC 231 kb)

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Shuo, Y., Zhang, C., Yang, X. et al. Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities. J Nat Med 73, 826–833 (2019). https://doi.org/10.1007/s11418-019-01324-5

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  • DOI: https://doi.org/10.1007/s11418-019-01324-5

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