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Two new alkaloids from Crinum asiaticum var. japonicum

Abstract

A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids—ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (−)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)—were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.

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Acknowledgements

This work was supported by JSPS KAKENHI (Grant numbers 2410293, 16K01921 to AO). We are grateful to Mr. Kazuo Sugimura (Shimanto City Hall, Kochi Prefecture, Japan) for his support of the plant collection.

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Correspondence to Ayumi Ohsaki.

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Endo, Y., Sugiura, Y., Funasaki, M. et al. Two new alkaloids from Crinum asiaticum var. japonicum. J Nat Med 73, 648–652 (2019). https://doi.org/10.1007/s11418-019-01304-9

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Keywords

  • Crinum asiaticum var. japonicum
  • Crinine alkaloid
  • Galanthamine alkaloid
  • Cytotoxicity
  • Acetylcholinesterase inhibitory activity