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Two new alkaloids from Crinum asiaticum var. japonicum

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Abstract

A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids—ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (−)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)—were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.

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Acknowledgements

This work was supported by JSPS KAKENHI (Grant numbers 2410293, 16K01921 to AO). We are grateful to Mr. Kazuo Sugimura (Shimanto City Hall, Kochi Prefecture, Japan) for his support of the plant collection.

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Authors and Affiliations

  1. College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo, 156-8550, Japan

    Yuta Endo, Yu Sugiura, Mariko Funasaki & Ayumi Ohsaki

  2. Biomaterials and Engineering, Tokyo Medical and Dental University, Surugadai, Kanda, 101-0062, Japan

    Hiroyuki Kagechika

  3. Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chuo-ku, Chiba, 260-8675, Japan

    Masami Ishibashi

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  1. Yuta Endo
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  2. Yu Sugiura
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  3. Mariko Funasaki
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  4. Hiroyuki Kagechika
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  5. Masami Ishibashi
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  6. Ayumi Ohsaki
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Correspondence to Ayumi Ohsaki.

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Endo, Y., Sugiura, Y., Funasaki, M. et al. Two new alkaloids from Crinum asiaticum var. japonicum. J Nat Med 73, 648–652 (2019). https://doi.org/10.1007/s11418-019-01304-9

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  • DOI: https://doi.org/10.1007/s11418-019-01304-9

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