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A review of the ethnopharmacology, phytochemistry, and pharmacology of Changium smyrnioides Wolff

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Abstract

Changium smyrnioides Wolff is a monotypic species of the genus Changium Wolff which is only found in eastern China. C. smyrnioides has been used as a traditional medicine for ages to treat cough, vomiting, nausea, megrim, and carbuncle. It is also widely used to brew medicated liquor and health tea with other herbs in order to moisten the lungs and nourish blood and yin. This review comprehensively summarizes the up-to-date information on the botanical characterization, distribution, traditional uses, ethnopharmacology, phytochemistry, pharmacology, and toxicity of C. smyrnioides based on studies published in recent years. Phytochemical investigations have revealed that phenylpropanoids, volatile oils, fatty acids, phytosterols, and other bioactive compounds are contained in C. smyrnioides. Crude extracts and monomeric compounds isolated from C. smyrnioides have significant effects on the respiratory, immune, and vascular systems and exhibit favourable activities such as antitussive, eliminating phlegm, anti-asthmatic, immunoregulatory, antioxidant, anti-tumor, anti-fatigue, anti-hypoxia, and anti-atherosclerotic effects. C. smyrnioides is a promising medicinal herb with immense therapeutic and health-promoting effects. Therefore, further studies on the bioactive compounds and mechanisms of C. smyrnioides are necessary. Additional clinical and toxicological studies are warranted to evaluate its safety.

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Acknowledgements

This study was supported by a grant (ZYY-2017-069) for the TCM (Traditional Chinese Medicine) Standardization Project from State Administration of TCM and Tianjin Applied Foundation and Frontier Technology Research Program (15JCQNJC13400). We thank professor Hua-Sheng Peng for providing the images of C. smyrnioides.

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Authors and Affiliations

  1. Inner Mongolia Institute of Traditional Chinese Medicine, No. 11 Jian Kang Street, Hohhot, Inner Mongolia, China

    Lu-Jing Lei, Wen-Le Wang & Min-Hui Li

  2. Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, Guangxi Province, China

    Min-Hui Li

  3. Baotou Medical College, No. 31 Construction Road, Baotou, Inner Mongolia, China

    Jie Wang & Min-Hui Li

  4. Department of Basic Science, Tianjin Agricultural University, Hua Feng Road, No. 36, Tianjin, China

    Li-juan Lv

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  1. Lu-Jing Lei
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Correspondence to Min-Hui Li.

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Lei, LJ., Wang, WL., Wang, J. et al. A review of the ethnopharmacology, phytochemistry, and pharmacology of Changium smyrnioides Wolff. J Nat Med 73, 1–10 (2019). https://doi.org/10.1007/s11418-018-1245-3

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