A new biflavonoid and a new triterpene from the leaves of Garcinia paucinervis and their biological activities
- 339 Downloads
A new biflavonoid, paucinervin K (1) and a new triterpene, 23-hydroxy-friedelin (2), together with eleven known compounds 3-13 were isolated from the leaves of Garcinia paucinervis. Their structures, including stereochemistry, were determined by spectroscopic analysis of NMR, MS, IR and ECD calculation and the octant rule. Some of the isolated compounds were tested for antiproliferative, α-glucosidase inhibitory and antioxidant activities in vitro. Compounds 1, 3, 4, 5 and 9 showed moderate preferential antioxidant and hypoglycemic activities. Compounds 3–6 and 9 exhibited potent growth inhibition against HepG-2 and PC-3 cell lines with IC50 values ranging from 1.02−10.05 μM.
KeywordsGarcinia paucinervis Biflavonoid Triterpene Antiproliferation Antioxidant α-Glucosidase
This study was financially supported by the National Natural Science Foundation of China (31570350, 21502121), Project Funded by China Postdoctoral Science Foundation (2015M570258), General Scientific Research Projects of Department of Education in Liaoning Province (L2014382), Young Teachers’ Scientific Research Fund Project of Shenyang Pharmaceutical University (QNJJ 2013501).
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest.
- 16.Fan QF, Na Z, Hu HB, Xu YK, Tang T (2012) Chemical constituents from stem barks of Garcinia paucinervis. Chin Tradit Herb Drugs 43:436–439Google Scholar
- 25.Wu LJ (1989) Optical rotatory dispersion and circular dichroic spectroscopy are applied in organic chemistry. J Shenyang Pharm Univ 6:148–156Google Scholar
- 27.Shen J, Yang JS (2007) A novel benzophenone from Garcinia cowa. Acta Chim Sin 65:1675–1678Google Scholar
- 33.Yu Y, Wang SS, Ding FG, Zhu JB, Zhao WJ (2010) Isolation and identification of the chemical constituents from Swertia yuannanensis. Chin J Med Chem 20:125–128Google Scholar
- 34.Liu HQ, An J, Lv HC (2015) Chemical constituents from Smilax hypoglauca. Chin J Exp Tradit Med Form 21:59–61Google Scholar
- 35.Lu GS, Lu WJ, Chen JY, Tan X, Huang JQ, Huang ZF (2015) Chemical constituents from Macrosolen cochinchinensis. Chin J Exp Tradit Med Form 21:44–46Google Scholar
- 36.Li FF, Guo ZQ, Chai XY, Tu PF (2012) Triterpenoids from the stems of Casearia velutina Bl. J Chin Pharm Sci 21:273–277Google Scholar
- 37.Hatano T, Edamatsu R, Hiramatsu M, Mori A, Fujita Y, Yasuhara T, Yoshida T, Okuda T (1989) Effects of the interaction of tannins with co-existing substances. VI. Effects of tannins and related ployphenols on superoxide anion radical, and on 1,1-diphenyl-2-picryhydrazyl radical. Chem Pharm Bull 37:2016–2021CrossRefGoogle Scholar