Journal of Natural Medicines

, Volume 71, Issue 1, pp 257–264 | Cite as

Gastroprotective effect of palmatine against acetic acid-induced gastric ulcers in rats

  • Ling Wang
  • Xue Wang
  • Su-Li Zhang
  • Xiao-Ming Zhu
  • Yan-Qi Liu
  • Zi-Jing Song
  • Wen-Juan Du
  • Jun Ji
  • Cheng-Long Cui
  • Xin He
  • Chun-Feng Zhang
  • Chang-Run Guo
  • Chong-Zhi Wang
  • Chun-Su Yuan
Original Paper


Gastric ulcers are one of the most common gastrointestinal disorders. The aim of this study was to investigate the gastroprotective activity and possible underlying mechanisms of palmatine against acetic acid-induced gastric ulcers in rats. Palmatine was administered orally for 7 consecutive days to treat ulcers. The ulcer area, ulcer inhibition rate, histological section, platelet-activating factor (PAF) level in serum, prostaglandin E2 (PGE2) level in gastric tissue, 5-hydroxytryptamine (5-HT) level in the brain and norepinephrine (NE) level in the adrenal glands were analyzed. Histological results showed that the ulcer areas were significantly decreased by both doses of palmatine (10 and 20 mg/kg/day) compared with the model group, and the ulcer inhibition rates were 51.42% and 60.92%, respectively. Palmatine treatment markedly increased the level of PGE2 and decreased PAF, compared with the model group; however, it had no significant effect on 5-HT and NE levels. The results indicated that palmatine may exert a gastroprotective effect against gastric ulcers, and the mechanisms might be associated with the anti-inflammatory status and the protection of gastric mucosa via increasing PGE2 and decreasing PAF rather than neurohumoral regulation through 5-HT and NE. Thus, palmatine is a potential drug for treatment of gastric ulcers.


Palmatine Gastroprotective action Acetic acid-induced gastric ulcer Anti-inflammation 



Platelet-activating factor


Prostaglandin E2






Sodium carboxymethylcellulose


Enzyme-linked immunosorbent assay


Sham-operated group


Model group


Omeprazole group


Weikangling capsule


Low-dose palmatine group


High-dose palmatine group




Image-Pro Plus


Standard error of measurement


One-way analysis of variance


Arachidonic acid


Phospholipase A2


Cyclooxygenase 2


Prostaglandin E synthase


Hypothalamic pituitary adrenal



This work was supported by the National Natural Science Foundation of China (81573565), the College Students Innovation Project for the R&D of Novel Drugs (J1030830) and National Training Programs of Innovation and Entrepreneurship for College Students.

Compliances with ethical standards

Conflict of interest

We have no conflict of interest in this research.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Ling Wang
    • 1
  • Xue Wang
    • 1
  • Su-Li Zhang
    • 1
  • Xiao-Ming Zhu
    • 1
  • Yan-Qi Liu
    • 1
  • Zi-Jing Song
    • 1
  • Wen-Juan Du
    • 1
  • Jun Ji
    • 1
  • Cheng-Long Cui
    • 1
  • Xin He
    • 2
  • Chun-Feng Zhang
    • 1
    • 3
  • Chang-Run Guo
    • 1
  • Chong-Zhi Wang
    • 3
  • Chun-Su Yuan
    • 3
  1. 1.State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjingChina
  2. 2.School of PharmacyNanjing University of Chinese MedicineNanjingChina
  3. 3.Department of Anesthesia and Critical CareTang Center of Herbal Medicine Research, University of ChicagoChicagoUSA

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