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Journal of Natural Medicines

, Volume 71, Issue 1, pp 238–248 | Cite as

Evaluation of the chemical quality of Sekkoku (石斛) in current Japanese commercial crude drugs: constituents of Flickingeria xantholeuca (Rchb. f.) A.D. Hawkes

  • Mei Muto
  • Haruka Asahina
  • Tatsufumi Yoshioka
  • Kazuo Ozaki
  • Makio Shibano
Original Paper
  • 218 Downloads

Abstract

In our investigation, most Shihu (石斛; Japanese name, Sekkoku) in current Japanese commercial crude drugs were from Flickingeria xantholeuca (Orchidaceae). As the index compounds, three new ent-pimarane-type diterpenes, flickinxthanthosides A–C (13), one known analogue (7), and three new ent-kaurane-type diterpenes, flickinxanthosides D (4) and E (5) and flickinxanthol A (6) were isolated from the stem of F. xantholeuca. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and chemical methods. We attempted to detect these index compounds from the MeOH extracts of other Dendrobium or Flickingeria plants using TLC and LC/MS.

Keywords

ent-Pimarane-type diterpene ent-Kaurane-type diterpene Glycoside Flickingeria xantholeuca Orchidaceae TLC LC/MS 

Notes

Acknowledgments

The authors are grateful to Dr. K. Minoura for NMR spectra recordings and Dr. M. Fujitake for mass spectra recordings at the Osaka University of Pharmaceutical Sciences. We thank Ms. Su Su Wai Lwin (Department of Agriculture, Ministry of Agriculture and Irrigation) for collaborating on the field survey in Myanmar.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  1. 1.Osaka University of Pharmaceutical SciencesTakatsukiJapan
  2. 2.National Defense Medicinal CollegeTokorozawaJapan
  3. 3.Research Institute of Medicinal Plant ResourcesShinnihonseiyaku Co., Ltd.IwakuniJapan

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